Effect of thalamic deep brain stimulation on swallowing in patients with essential tremor.

Autor: Lapa S; Department of Neurology, University Hospital Frankfurt, Frankfurt, Germany., Claus I; Department of Neurology, University Hospital Muenster, Muenster, Germany., Reitz SC; Department of Neurology, University Hospital Frankfurt, Frankfurt, Germany., Quick-Weller J; Department of Neurosurgery, University Hospital Frankfurt, Frankfurt, Germany., Sauer S; Department of Neurology, University Hospital Muenster, Muenster, Germany., Colbow S; Department of Neurology, University Hospital Muenster, Muenster, Germany., Nasari C; Department of Neurology, University Hospital Frankfurt, Frankfurt, Germany., Dziewas R; Department of Neurology, University Hospital Muenster, Muenster, Germany., Kang JS; Department of Neurology, University Hospital Frankfurt, Frankfurt, Germany., Baudrexel S; Department of Neurology, University Hospital Frankfurt, Frankfurt, Germany., Warnecke T; Department of Neurology, University Hospital Muenster, Muenster, Germany.
Jazyk: angličtina
Zdroj: Annals of clinical and translational neurology [Ann Clin Transl Neurol] 2020 Jul; Vol. 7 (7), pp. 1174-1180. Date of Electronic Publication: 2020 Jun 16.
DOI: 10.1002/acn3.51099
Abstrakt: Objective: Deep brain stimulation (DBS) of the ventral intermediate nucleus (VIM) is a mainstay treatment for severe and drug-refractory essential tremor (ET). Although stimulation-induced dysarthria has been extensively described, possible impairment of swallowing has not been systematically investigated yet.
Methods: Twelve patients with ET and bilateral VIM-DBS with self-reported dysphagia after VIM-DBS were included. Swallowing function was assessed clinically and using by flexible endoscopic evaluation of swallowing in the stim-ON and in the stim-OFF condition. Presence, severity, and improvement of dysphagia were recorded.
Results: During stim-ON, the presence of dysphagia could be objectified in all patients, 42% showing mild, 42% moderate, and 16 % severe dysphagia. During stim-OFF, all patients experienced a statistically significant improvement of swallowing function.
Interpretation: VIM-DBS may have an impact on swallowing physiology in ET-patients. Further studies to elucidate the prevalence and underlying pathophysiological mechanisms are warranted.
(© 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.)
Databáze: MEDLINE
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