Nail enthesis ultrasound and automated software-guided assessment of bilateral common carotid intima-media thickness in psoriasis and psoriatic arthritis: is there a correlation with clinical and laboratory findings?

Autor:	Mendonça JA; Serviço de Reumatologia, Pontifícia Universidade Católica de Campinas, São Paulo, Brazil.; Health Sciences Post-Graduation Program, PUC-Campinas - SP-Brazil Research Group: Diagnostics and Clinical and Surgical Therapy, São Paulo, Brazil., Pansani LN; Serviço de Reumatologia, Pontifícia Universidade Católica de Campinas, São Paulo, Brazil., Mimoto MB; Serviço de Reumatologia, Pontifícia Universidade Católica de Campinas, São Paulo, Brazil., Ferreira ITG; Serviço de Reumatologia, Pontifícia Universidade Católica de Campinas, São Paulo, Brazil., Sanches FB; Serviço de Reumatologia, Pontifícia Universidade Católica de Campinas, São Paulo, Brazil., de Campos Ferreira Pinto T; Serviço de Reumatologia, Pontifícia Universidade Católica de Campinas, São Paulo, Brazil., Leandro-Merhi VA; Health Sciences Post-Graduation Program, PUC-Campinas - SP-Brazil Research Group: Diagnostics and Clinical and Surgical Therapy, São Paulo, Brazil., de Aquino JLB; Health Sciences Post-Graduation Program, PUC-Campinas - SP-Brazil Research Group: Diagnostics and Clinical and Surgical Therapy, São Paulo, Brazil.; Serviço de Clínica Cirúrgica e Pós Graduação da Pontifícia Universidade Católica de Campinas, São Paulo, Brazil.
Jazyk:	angličtina
Zdroj:	Drugs in context [Drugs Context] 2020 Jun 03; Vol. 9. Date of Electronic Publication: 2020 Jun 03 (Print Publication: 2020).
DOI:	10.7573/dic.2020-1-2
Abstrakt:	Background: Ultrasound (US) in psoriasis (PsO) and psoriatic arthritis (PsA) is an important tool in several situations to detect joint ecostructural damage as well as other tissue alterations, such as those that occur in the larger vessels. The objective of this study was to detect and correlate the changes that indicate the inflammatory and atherosclerotic process in two groups of patients, using nail US and carotid artery intima-media thickness radiofrequency (RF) software. Methods: A total of 30 patients diagnosed with (PsO) and (PsA) were selected. About 15 patients were present in each group, assigned by the Dermatology and Rheumatology Service of the Universidade Pontifícia Católica de Campinas , São Paulo, Brazil, and were assessed using carotid artery US (radiofrequency quality intima-media thickness [RF-QIMT]), joint US, clinical evaluation, and laboratory tests. Results: Spearman and Pearson correlations between US variables per group were Psoriasis Area and Severity Index (PASI) and loss of the nail pattern trilaminar: r =0.658, p =0.015; Framingham Score (FS) and Internal Resistance Index (IR): 0.351 to 0.526, p =0.034 to 0.002; the significant correlations by the Bayesian factor ( BF ) were those with a BF greater than 2.5, between QIMT expected with FS: r =0.677, BF=10.06, with total cholesterol: r =0.5232, BF=2.60, and QIMT-RF with low density lipoproteins: r =0.633, BF=3.70. Conclusion: The use of US in the evaluation of these patients showed significant correlations between clinical and laboratory measures, characterized by QIMT and FS as well as changes in nail insertion. Future studies may demonstrate an even better interaction. Competing Interests: Disclosure and potential conflicts of interest: The authors declare that they have no conflicts of interest. The International Committee of Medical Journal Editors (ICMJE) Potential Conflicts of Interests form for the authors is available for download at: https://www.drugsincontext.com/wp-content/uploads/2020/05/dic.2020-1-2-COI.pdf (Copyright © 2020 Mendonça JA, Pansani LN, Mimoto MB, Ferreira ITG, Sanches FB, Pinto TFC, Leandro-Merhi VA, Aquino JLB.)
Databáze:	MEDLINE
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