Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer.

Autor: Strakova A; Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK., Nicholls TJ; Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, Sweden.; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle Upon Tyne, UK., Baez-Ortega A; Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK., Ní Leathlobhair M; Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK., Sampson AT; Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK., Hughes K; Department of Veterinary Medicine, University of Cambridge, Cambridge, UK., Bolton IAG; Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK., Gori K; Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK., Wang J; Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK., Airikkala-Otter I; Worldwide Veterinary Service, International Training Center, Tamil Nadu, India., Allen JL; Animal Management in Rural and Remote Indigenous Communities (AMRRIC), Darwin, Australia., Allum KM; World Vets, Gig Harbor, USA., Arnold CL; Hopkins Belize Humane Society, Hopkins, Belize., Bansse-Issa L; Animal Shelter, Stichting Dierenbescherming Suriname, Paramaribo, Suriname., Bhutia TN; Sikkim Anti-Rabies and Animal Health Programme, Department of Animal Husbandry, Livestock, Fisheries and Veterinary Services, Government of Sikkim, Sikkim, India., Bisson JL; Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK., Blank K; Hopkins Belize Humane Society, Hopkins, Belize., Briceño C; ConserLab, Animal Preventive Medicine Department, Faculty of Animal and Veterinary Sciences, University of Chile, Santiago, Chile., Castillo Domracheva A; Corozal Veterinary Hospital, University of Panamá, Panama City, Republic of Panama., Corrigan AM; St. George's University, True Blue, Grenada., Cran HR; The Nakuru District Veterinary Scheme Ltd, Nakuru, Kenya., Crawford JT; Animal Medical Centre, Belize City, Belize., Cutter SM; Animal Management in Rural and Remote Indigenous Communities (AMRRIC), Darwin, Australia., Davis E; International Animal Welfare Training Institute, UC Davis School of Veterinary Medicine, Davis, USA., de Castro KF; Centro Universitário de Rio Preto (UNIRP), São José do Rio Preto, São Paulo, Brazil., De Nardi AB; School of Agricultural and Veterinary Sciences, São Paulo State University (UNESP), Jaboticabal, Brazil., de Vos AP; Ladybrand Animal Clinic, Ladybrand, South Africa., Delgadillo Keenan L; Veterinary Clinic Sr. Dog's, Guadalajara, Mexico., Donelan EM; Animal Management in Rural and Remote Indigenous Communities (AMRRIC), Darwin, Australia., Espinoza Huerta AR; World Vets Latin America Veterinary Training Center, Granada, Nicaragua., Faramade IA; National Veterinary Research Institute, Vom, Nigeria., Fazil M; Animal Clinic, Mombasa, Kenya., Fotopoulou E; Intermunicipal Stray Animals Care Centre (DIKEPAZ), Perama, Greece., Fruean SN; Animal Protection Society of Samoa, Apia, Samoa., Gallardo-Arrieta F; Faculty of Veterinary Science, University of Zulia, Maracaibo, Venezuela., Glebova O; Veterinary Clinic BIOCONTROL, Moscow, Russia., Gouletsou PG; Faculty of Veterinary Medicine, School of Health Sciences, University of Thessaly, Karditsa, Greece., Häfelin Manrique RF; Veterinary Clinic El Roble, Animal Healthcare Network, Faculty of Animal and Veterinary Sciences, University of Chile, Santiago de Chile, Chile., Henriques JJGP; OnevetGroup, Hospital Veterinário Berna, Lisboa, Portugal., Horta RS; Universidade Vila Velha, Vila Velha, Brazil., Ignatenko N; Veterinary Clinic Zoovetservis, Kiev, Ukraine., Kane Y; École Inter-états des Sciences et Médecine Vétérinaires de Dakar, Dakar, Senegal., King C; World Vets, Gig Harbor, USA., Koenig D; World Vets, Gig Harbor, USA., Krupa A; Department of Small Animal Medicine, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands., Kruzeniski SJ; World Vets Latin America Veterinary Training Center, Granada, Nicaragua., Lanza-Perea M; St. George's University, True Blue, Grenada., Lazyan M; Vetexpert Veterinary Group, Yerevan, Armenia., Lopez Quintana AM; Lopez Quintana Veterinary Clinic, Maldonado, Uruguay., Losfelt T; Clinique Veterinaire de Grand Fond, Saint Gilles les Bains, Reunion, France., Marino G; Department of Veterinary Sciences, University of Messina, Messina, Italy., Martínez Castañeda S; Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca, Mexico., Martínez-López MF; School of Veterinary Medicine, Universidad de las Américas, Quito, Ecuador., Masuruli BM; Veterinary Council of Tanzania, Dar-es-Salaam, Tanzania., Meyer M; Touray & Meyer Vet Clinic, Serrekunda, The Gambia., Migneco EJ; Hillside Animal Hospital, St. Louis, USA., Nakanwagi B; The Kampala Veterinary Surgery, Kampala, Uganda., Neal KB; Asavet Veterinary Charities, Tucson, USA., Neunzig W; World Vets, Gig Harbor, USA., Nixon SJ; Vets Beyond Borders, Bylakuppe, India., Ortega-Pacheco A; Faculty of Veterinary Medicine, Autonomous University of Yucatan, Merida, Mexico., Pedraza-Ordoñez F; Laboratorio de Patología Veterinaria, Universidad de Caldas, Manizales, Colombia., Peleteiro MC; Centre for Interdisciplinary Research in Animal Health (CIISA), Faculty of Veterinary Medicine, University of Lisbon, Lisboa, Portugal., Polak K; Four Paws International, Vienna, Austria., Pye RJ; Vets Beyond Borders, The Rocks, Australia., Ramirez-Ante JC; Laboratorio de Patología Veterinaria, Universidad de Caldas, Manizales, Colombia., Reece JF; Help in Suffering, Jaipur, India., Rojas Gutierrez J; Veterinary Clinic Dr José Rojas, Los Andes, Chile., Sadia H; Department of Biotechnology, Balochistan University of Information Technology, Engineering and Management Sciences, Quetta, Pakistan., Schmeling SK; Corozal Veterinary Clinic, Corozal Town, Belize., Shamanova O; Veterinary Clinic Vetmaster, Ramenskoye, Russia., Sherlock AG; Vets Beyond Borders, The Rocks, Australia., Steenland-Smit AE; Animal Shelter, Stichting Dierenbescherming Suriname, Paramaribo, Suriname., Svitich A; State Hospital of Veterinary Medicine, Kamianske, Ukraine., Tapia Martínez LJ; World Vets Latin America Veterinary Training Center, Granada, Nicaragua., Thoya Ngoka I; Jomo Kenyatta University of Agriculture and Technology, Juja, Kenya., Torres CG; Laboratory of Biomedicine and Regenerative Medicine, Department of Clinical Sciences, Faculty of Animal and Veterinary Sciences, University of Chile, Santiago, Chile., Tudor EM; Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Melbourne, Australia., van der Wel MG; Animal Anti Cruelty League, Port Elizabeth, South Africa., Vițălaru BA; Clinical Sciences Department, Faculty of Veterinary Medicine Bucharest, Bucharest, Romania., Vural SA; Department of Pathology, Faculty of Veterinary Medicine, Ankara University, Ankara, Turkey., Walkinton O; Vets Beyond Borders, The Rocks, Australia., Wehrle-Martinez AS; Faculty of Veterinary Sciences, National University of Asuncion, San Lorenzo, Paraguay., Widdowson SAE; Lilongwe Society for Protection and Care of Animals (LSPCA), Lilongwe, Malawi., Zvarich I; Veterinary clinic Canine Heart, Yelizovo, Russia., Chinnery PF; MRC-Mitochondrial Biology Unit & Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Falkenberg M; Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, Sweden., Gustafsson CM; Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, Sweden., Murchison EP; Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK. epm27@cam.ac.uk.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2020 Jun 16; Vol. 11 (1), pp. 3059. Date of Electronic Publication: 2020 Jun 16.
DOI: 10.1038/s41467-020-16765-w
Abstrakt: Autonomous replication and segregation of mitochondrial DNA (mtDNA) creates the potential for evolutionary conflict driven by emergence of haplotypes under positive selection for 'selfish' traits, such as replicative advantage. However, few cases of this phenomenon arising within natural populations have been described. Here, we survey the frequency of mtDNA horizontal transfer within the canine transmissible venereal tumour (CTVT), a contagious cancer clone that occasionally acquires mtDNA from its hosts. Remarkably, one canine mtDNA haplotype, A1d1a, has repeatedly and recently colonised CTVT cells, recurrently replacing incumbent CTVT haplotypes. An A1d1a control region polymorphism predicted to influence transcription is fixed in the products of an A1d1a recombination event and occurs somatically on other CTVT mtDNA backgrounds. We present a model whereby 'selfish' positive selection acting on a regulatory variant drives repeated fixation of A1d1a within CTVT cells.
Databáze: MEDLINE