| Autor: |
Kolonko A; Department of Nephrology, Transplantation and Internal Medicine; Medical University of Silesia, Francuska 20, 40-027 Katowice, Poland., Jurys M; Department of Ophthalmology, School of Medicine in Katowice, Medical University of Silesia in Katowice, Ceglana 35, 40-514 Katowice, Poland., Sirek S; Department of Ophthalmology, School of Medicine in Katowice, Medical University of Silesia in Katowice, Ceglana 35, 40-514 Katowice, Poland.; Prof. Kornel Gibiński University Clinic Centre of Medical University of Silesia, Ceglana 35, 40-514 Katowice, Poland., Dwulit T; Department of Nephrology, Transplantation and Internal Medicine; Medical University of Silesia, Francuska 20, 40-027 Katowice, Poland., Pojda-Wilczek D; Department of Ophthalmology, School of Medicine in Katowice, Medical University of Silesia in Katowice, Ceglana 35, 40-514 Katowice, Poland.; Prof. Kornel Gibiński University Clinic Centre of Medical University of Silesia, Ceglana 35, 40-514 Katowice, Poland., Więcek A; Department of Nephrology, Transplantation and Internal Medicine; Medical University of Silesia, Francuska 20, 40-027 Katowice, Poland. |
| Abstrakt: |
In kidney transplant recipients (KTRs), uraemia-induced central nervous system damage partly subsides, while the long-lasting exposure to tacrolimus may cause pathologic visual evoked potentials (VEP) findings, which have not been investigated yet. Thus, the aim of the present study was to assess the effect of tacrolimus maintenance treatment on bioelectrical function of optic nerves in stable KTRs. Sixty-five stable KTRs were enrolled, including 30 patients treated with twice-daily (Prograf) and 35 patients treated with prolonged once-daily (Advagraf) tacrolimus formulation. In all patients, pattern and flash VEP measurements were performed. Tacrolimus dosing and exposure were also analyzed. Overall, 129 eyes were analyzed. In pattern VEP, both (1°) and (15') latencies of P100 waves were significantly longer, whereas (1°) and (15') amplitudes were lower in the Advagraf group as compared with the Prograf group. Multivariate regression analyses revealed that the use of Advagraf (vs. Prograf) was independently associated with longer (1°) and (15') P100 latencies and lower corresponding amplitudes, whereas log tacrolimus daily dose was only related to amplitudes in a whole study group. In flash VEP, log tacrolimus trough level was associated with negative changes in P2 wave amplitude irrespective of tacrolimus formulation, whereas its association with P2 latency was observed only in the Prograf group. Both the type of tacrolimus formulation and drug exposure influenced the VEP parameters in stable KTRs. |
