Hallmarks of aging Drosophila intestinal stem cells.

Autor: Rodriguez-Fernandez IA; Immunology Discovery, Genentech, Inc. 1 DNA Way, South San Francisco, CA, 94080, USA., Tauc HM; Immunology Discovery, Genentech, Inc. 1 DNA Way, South San Francisco, CA, 94080, USA., Jasper H; Immunology Discovery, Genentech, Inc. 1 DNA Way, South San Francisco, CA, 94080, USA. Electronic address: jasperh@gene.com.
Jazyk: angličtina
Zdroj: Mechanisms of ageing and development [Mech Ageing Dev] 2020 Sep; Vol. 190, pp. 111285. Date of Electronic Publication: 2020 Jun 13.
DOI: 10.1016/j.mad.2020.111285
Abstrakt: The age-associated decline of regenerative capacity in many tissues is a consequence of stem cell intrinsic and extrinsic perturbations that are only beginning to be understood. To gain insight into mechanisms of this age-related decline, a comprehensive understanding of these perturbations is necessary. Drosophila intestinal stem cells (ISCs) have served as a prime model in which to explore these age-related changes, and in which to identify intervention strategies to improve regenerative capacity and extend lifespan. In this review, we summarize and discuss important work that has contributed to our understanding of how aging impacts ISC regulation in relation to well-described "hallmarks" of aging.
(Copyright © 2020. Published by Elsevier B.V.)
Databáze: MEDLINE
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