Fabrication and characterization of remineralizing dental composites containing hydroxyapatite nanoparticles.

Autor: Jardim RN; Analytical Laboratory of Restorative Biomaterials - LABiom-R, School of Dentistry, Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brazil., Rocha AA; Department of Analytical Chemistry and NAB - Nucleus of Biomass Studies and Water Management - Federal Fluminense University, Niterói, Rio de Janeiro, Brazil., Rossi AM; Brazilian Center for Physics Research, Rio de Janeiro, Brazil., de Almeida Neves A; Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; Department of Paediatric Dentistry, King's College London, London, UK., Portela MB; Odontopediatric Division, School of Dentistry, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil., Lopes RT; Laboratory for Nuclear Instrumentation, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil., Pires Dos Santos TM; Laboratory for Nuclear Instrumentation, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil., Xing Y; High-resolution Electron Microscopy Lab, Advanced Characterization Center for Petroleum Industry, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil., Moreira da Silva E; Analytical Laboratory of Restorative Biomaterials - LABiom-R, School of Dentistry, Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brazil. Electronic address: em_silva@id.uff.br.
Jazyk: angličtina
Zdroj: Journal of the mechanical behavior of biomedical materials [J Mech Behav Biomed Mater] 2020 Sep; Vol. 109, pp. 103817. Date of Electronic Publication: 2020 Apr 28.
DOI: 10.1016/j.jmbbm.2020.103817
Abstrakt: The aim of this study was to fabricate and characterize dental composites containing hydroxyapatite nanoparticles (HApNPs). Four dental composites were produced from the same organic matrix (70 wt% Bis-GMA and 30 wt% TEGDMA), with partial replacement of BaBSi particles (65 wt%) by HApNPs in the following concentrations (wt%): E0 (0) - control, E10 (10), E20 (20) and E30 (30). Ca 2+ and PO 4 3- release was evaluated in solutions with different pHs (4, 5.5, and 7) using atomic emission spectroscopy with microwave-induced nitrogen plasma while the enamel remineralization potential was evaluated in caries-like enamel lesions induced by S. mutans biofilm using micro-CT. The following properties were characterized: degree of conversion (DC%), microhardness (KHN), flexural strength (FS), elastic modulus (EM) and translucency (TP). The higher the HApNPs content, the higher the Ca 2+ and PO 4 3- release. The ions release was influenced by pH (4 > 5.5 > 7) (p < 0.05). All composites loaded with HApNPs were able to remineralize the enamel (E30 = E20 > E10) (p < 0.05). Contrarily, E0 was not able of recovering the enamel mineral loss. E0 and E10 presented highest DC%, while E20 and E30 showed similar and lowest DC%. KHN and FS were decreased with the addition of HApNPs, while EM was not influenced by the incorporation of HApNPs. E10 presented statistically similar TP to E0, while this property decreased for E20 and E30 (p < 0.05). Incorporation of HApNPs into dental composites promoted enamel remineralization, mainly at potentially cariogenic pH (= 4), while maintained their overall performance in terms of physicomechanical properties.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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