The value of circulating microRNAs for early diagnosis of B-cell lymphoma: A case-control study on historical samples.

Autor: Jørgensen S; Department of Clinical Immunology, Naestved Hospital, Naestved, Denmark.; Department of Science and Environment, Roskilde University, Roskilde, Denmark.; Professionshøjskolen Absalon, Naestved, Denmark., Paulsen IW; Department of Clinical Immunology, Naestved Hospital, Naestved, Denmark.; Department of Science and Environment, Roskilde University, Roskilde, Denmark., Hansen JW; Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Tholstrup D; Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Hother C; Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Sørensen E; Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Petersen MS; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark., Nielsen KR; Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark., Rostgaard K; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Larsen MAH; Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Brown PN; Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Ralfkiær E; Department of Pathology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Homburg KM; Department of Clinical Immunology, Naestved Hospital, Naestved, Denmark., Hjalgrim H; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Erikstrup C; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark., Ullum H; Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Troelsen J; Department of Science and Environment, Roskilde University, Roskilde, Denmark., Grønbæk K; Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Pedersen OB; Department of Clinical Immunology, Naestved Hospital, Naestved, Denmark. olbp@regionsjaelland.dk.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2020 Jun 15; Vol. 10 (1), pp. 9637. Date of Electronic Publication: 2020 Jun 15.
DOI: 10.1038/s41598-020-66062-1
Abstrakt: MicroRNAs are small regulatory RNAs that are deregulated in a wide variety of human cancers, including different types of B-cell lymphoma. Nevertheless, the feasibility of circulating microRNA for early diagnosis of B-cell lymphoma has not been established. To address the possibility of detecting specific circulating microRNAs years before a B-cell lymphoma is diagnosed, we studied the plasma expression of microRNA first in pre-treatment samples from patients with diffuse large B-cell lymphoma and subsequently in repository samples from blood donors who later developed B-cell lymphomas. In addition, we studied the microRNA expression in the diagnostic lymphoma biopsy. The most strongly induced (miR-326) and suppressed (miR-375) plasma microRNA at diagnosis, when compared with healthy blood donors, were also substantially up- or down-regulated in plasma repository samples taken from several months to up to two years before the blood donors were diagnosed with B-cell lymphoma. Importantly, at these time points the donors had no signs of disease and felt healthy enough to donate blood. In conclusion, this first study of plasma microRNA profiles from apparently healthy individuals, taken several years before B-cell lymphoma diagnosis, suggests that plasma microRNA profiles may be predictive of lymphoma development.
Databáze: MEDLINE
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