Serum levels of nesfatin-1 and irisin in obese children.

Autor: Dokumacioglu E; Department of Nutrition and Dietetics, Faculty of Healthy Sciences, Artvin Çoruh University, Artvin, Turkey., Iskender H; Department of Nutrition and Dietetics, Faculty of Healthy Sciences, Artvin Çoruh University, Artvin, Turkey., Sahin A; Arzu Sahin, Department of Physiology, Faculty of Medicine, Uşak University, Uşak, Turkey., Erturk EY; Emine Yurdakul Erturk, Faculty of Medicine, Pediatric Health and Diseases Department, Ordu University, Ordu, Turkey., Kaynar O; Ozgur Kaynar, Department of Biochemistry, Faculty of Veterinary Medicine, Ataturk University, Erzurum, Turkey.
Jazyk: angličtina
Zdroj: European cytokine network [Eur Cytokine Netw] 2020 Mar 01; Vol. 31 (1), pp. 39-43.
DOI: 10.1684/ecn.2020.0444
Abstrakt: Along with the developing technology in the modern age, physical activity had decreased considerably in children and adolescents alike with a concomittant and rapid increase in the prevalence of childhood obsesity. The purpose of the present study is to measure the levels of serum nesfatin-1 and irisin in obese children. The present study was carried out with a total of 62 children, including 32 obese children diagnosed between June 2017 and October 2017 and 30 healthy children. Serum nesfatin-1, irisin, SOD, MDA, fasting blood glucose, total cholesterol (TC), triglyceride (TG), HDL-C, LDL-C, aspartate amino transferase (AST), alanine amino transferase (ALT)), blood urea nitrogen (BUN), C-reactive protein (CRP), calcium (Ca), sodium (Na), potassium (P), chromium (Cr), ferritin, and vitamin B 12 data were collected for each patient. In our study, mean nesfatin-1 and SOD values of the obesity group were lower than those of the control group (p <0.05, p <0.001), whereas irisin and MDA values were higher than those of the control group (p <0.001). Childhood obesity is still a significant global problem, despite increased social awareness and numerous preventive healthcare interventions. We believe that all the prospective studies to be carried out to evaluate the relationship between obesity-irisin-nesfatin-1 triad, will make positive contributions to treatment of obesity.
Databáze: MEDLINE
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