Olfactory and Gustatory Dysfunction as an Early Identifier of COVID-19 in Adults and Children: An International Multicenter Study.

Autor: Qiu C; Center of Stomatology, Shanghai Public Health Clinical Center, Shanghai, China., Cui C; ENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, China., Hautefort C; Department of Head and Neck Surgery, Hopital Lariboisiere, University of Paris, Paris, France., Haehner A; Smell and Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany., Zhao J; Center of Pediatrics, Shanghai Public Health Clinical Center, Shanghai, China., Yao Q; Department of Otorhinolaryngology, Chinese and Western Medicine Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Zeng H; Department of Cardiovascularology, The Third People's Hospital of Shenzhen, Shenzhen, China., Nisenbaum EJ; Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, USA., Liu L; Department of Infectious Diseases, Shanghai Public Health Clinical Center, Shanghai, China., Zhao Y; ENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, China., Zhang D; Department of Otolaryngology, The Third People's Hospital of Shenzhen, Shenzhen, China., Levine CG; Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, USA., Cejas I; Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, USA., Dai Q; ENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, China., Zeng M; Department of Infectious Diseases, Children's Hospital of Fudan University, Shanghai, China., Herman P; Department of Head and Neck Surgery, Hopital Lariboisiere, University of Paris, Paris, France., Jourdaine C; Department of Head and Neck Surgery, Hopital Lariboisiere, University of Paris, Paris, France., de With K; Division of Infectious Diseases, University Hospital Carl Gustav Carus at the TU Dresden, Dresden, Germany., Draf J; Smell and Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany., Chen B; ENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, China., Jayaweera DT; Department of Medicine, Division of Infectious Diseases, University of Miami Miller School of Medicine, Miami, Florida, USA., Denneny JC 3rd; American Academy of Otolaryngology-Head and Neck Surgery, Alexandria, Virginia, USA., Casiano R; Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, USA., Yu H; ENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, China., Eshraghi AA; Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, USA., Hummel T; Smell and Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany., Liu X; Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, USA., Shu Y; ENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, China., Lu H; Department of Infectious Diseases, Shanghai Public Health Clinical Center, Shanghai, China.
Jazyk: angličtina
Zdroj: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery [Otolaryngol Head Neck Surg] 2020 Oct; Vol. 163 (4), pp. 714-721. Date of Electronic Publication: 2020 Jun 16.
DOI: 10.1177/0194599820934376
Abstrakt: Objective: To evaluate the prevalence and characteristics of olfactory or gustatory dysfunction in coronavirus disease 2019 (COVID-19) patients.
Study Design: Multicenter case series.
Setting: Five tertiary care hospitals (3 in China, 1 in France, 1 in Germany).
Subjects and Methods: In total, 394 polymerase chain reaction (PCR)-confirmed COVID-19-positive patients were screened, and those with olfactory or gustatory dysfunction were included. Data including demographics, COVID-19 severity, patient outcome, and the incidence and degree of olfactory and/or gustatory dysfunction were collected and analyzed. The Questionnaire of Olfactory Disorders (QOD) and visual analog scale (VAS) were used to quantify olfactory and gustatory dysfunction, respectively. All subjects at 1 hospital (Shanghai) without subjective olfactory complaints underwent objective testing.
Results: Of 394 screened subjects, 161 (41%) reported olfactory and/or gustatory dysfunction and were included. Incidence of olfactory and/or gustatory disorders in Chinese (n = 239), German (n = 39), and French (n = 116) cohorts was 32%, 69%, and 49%, respectively. The median age of included subjects was 39 years, 92 of 161 (57%) were male, and 10 of 161 (6%) were children. Of included subjects, 10% had only olfactory or gustatory symptoms, and 19% had olfactory and/or gustatory complaints prior to any other COVID-19 symptom. Of subjects with objective olfactory testing, 10 of 90 demonstrated abnormal chemosensory function despite reporting normal subjective olfaction. Forty-three percent (44/102) of subjects with follow-up showed symptomatic improvement in olfaction or gustation.
Conclusions: Olfactory and/or gustatory disorders may represent early or isolated symptoms of severe acute respiratory syndrome coronavirus 2 infection. They may serve as a useful additional screening criterion, particularly for the identification of patients in the early stages of infection.
Databáze: MEDLINE
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