Development of Microstructural and Morphological Cortical Profiles in the Neonatal Brain.

Autor:	Fenchel D; MRC Centre for Neurodevelopmental Disorders, King's College London, London, SE1 1UL, UK.; Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.; Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK., Dimitrova R; Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.; Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.; Department of Perinatal Imaging & Health, School of Biomedical Engineering & Imaging Sciences, Centre for the Developing Brain, King's College London, London, SE1 7EH, UK., Seidlitz J; Developmental Neurogenomics Unit, National Institute of Mental Health, Bethesda, MD 20892, USA.; Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, UK., Robinson EC; Department of Biomedical Engineering, School of Biomedical Engineering & Imaging Sciences, King's College London, London, SE1 7EU, UK., Batalle D; Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.; Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.; Department of Perinatal Imaging & Health, School of Biomedical Engineering & Imaging Sciences, Centre for the Developing Brain, King's College London, London, SE1 7EH, UK., Hutter J; Department of Perinatal Imaging & Health, School of Biomedical Engineering & Imaging Sciences, Centre for the Developing Brain, King's College London, London, SE1 7EH, UK., Christiaens D; Department of Perinatal Imaging & Health, School of Biomedical Engineering & Imaging Sciences, Centre for the Developing Brain, King's College London, London, SE1 7EH, UK., Pietsch M; Department of Perinatal Imaging & Health, School of Biomedical Engineering & Imaging Sciences, Centre for the Developing Brain, King's College London, London, SE1 7EH, UK., Brandon J; Department of Perinatal Imaging & Health, School of Biomedical Engineering & Imaging Sciences, Centre for the Developing Brain, King's College London, London, SE1 7EH, UK., Hughes EJ; Department of Perinatal Imaging & Health, School of Biomedical Engineering & Imaging Sciences, Centre for the Developing Brain, King's College London, London, SE1 7EH, UK., Allsop J; Department of Perinatal Imaging & Health, School of Biomedical Engineering & Imaging Sciences, Centre for the Developing Brain, King's College London, London, SE1 7EH, UK., O'Keeffe C; Department of Perinatal Imaging & Health, School of Biomedical Engineering & Imaging Sciences, Centre for the Developing Brain, King's College London, London, SE1 7EH, UK., Price AN; Department of Perinatal Imaging & Health, School of Biomedical Engineering & Imaging Sciences, Centre for the Developing Brain, King's College London, London, SE1 7EH, UK., Cordero-Grande L; Department of Perinatal Imaging & Health, School of Biomedical Engineering & Imaging Sciences, Centre for the Developing Brain, King's College London, London, SE1 7EH, UK., Schuh A; Biomedical Image Analysis Group, Department of Computing, Imperial College London, London, SW7 2AZ, UK., Makropoulos A; Biomedical Image Analysis Group, Department of Computing, Imperial College London, London, SW7 2AZ, UK., Passerat-Palmbach J; Biomedical Image Analysis Group, Department of Computing, Imperial College London, London, SW7 2AZ, UK., Bozek J; Faculty of Electrical Engineering and Computing, University of Zagreb, Zagreb, 10000, Croatia., Rueckert D; Biomedical Image Analysis Group, Department of Computing, Imperial College London, London, SW7 2AZ, UK., Hajnal JV; Department of Perinatal Imaging & Health, School of Biomedical Engineering & Imaging Sciences, Centre for the Developing Brain, King's College London, London, SE1 7EH, UK., Raznahan A; Developmental Neurogenomics Unit, National Institute of Mental Health, Bethesda, MD 20892, USA., McAlonan G; MRC Centre for Neurodevelopmental Disorders, King's College London, London, SE1 1UL, UK.; Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.; Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.; South London and Maudsley NHS Foundation Trust, London, SE5 8AZ, UK., Edwards AD; MRC Centre for Neurodevelopmental Disorders, King's College London, London, SE1 1UL, UK.; Department of Perinatal Imaging & Health, School of Biomedical Engineering & Imaging Sciences, Centre for the Developing Brain, King's College London, London, SE1 7EH, UK., O'Muircheartaigh J; MRC Centre for Neurodevelopmental Disorders, King's College London, London, SE1 1UL, UK.; Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.; Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.; Department of Perinatal Imaging & Health, School of Biomedical Engineering & Imaging Sciences, Centre for the Developing Brain, King's College London, London, SE1 7EH, UK.
Jazyk:	angličtina
Zdroj:	Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2020 Oct 01; Vol. 30 (11), pp. 5767-5779.
DOI:	10.1093/cercor/bhaa150
Abstrakt:	Interruptions to neurodevelopment during the perinatal period may have long-lasting consequences. However, to be able to investigate deviations in the foundation of proper connectivity and functional circuits, we need a measure of how this architecture evolves in the typically developing brain. To this end, in a cohort of 241 term-born infants, we used magnetic resonance imaging to estimate cortical profiles based on morphometry and microstructure over the perinatal period (37-44 weeks postmenstrual age, PMA). Using the covariance of these profiles as a measure of inter-areal network similarity (morphometric similarity networks; MSN), we clustered these networks into distinct modules. The resulting modules were consistent and symmetric, and corresponded to known functional distinctions, including sensory-motor, limbic, and association regions, and were spatially mapped onto known cytoarchitectonic tissue classes. Posterior regions became more morphometrically similar with increasing age, while peri-cingulate and medial temporal regions became more dissimilar. Network strength was associated with age: Within-network similarity increased over age suggesting emerging network distinction. These changes in cortical network architecture over an 8-week period are consistent with, and likely underpin, the highly dynamic processes occurring during this critical period. The resulting cortical profiles might provide normative reference to investigate atypical early brain development. (© The Author(s) 2020. Published by Oxford University Press.)
Databáze:	MEDLINE
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