Intravenous regular insulin is an efficient and safe procedure for obtaining high-quality cardiac 18 F-FDG PET images: an open-label, single-center, randomized controlled prospective trial.

Autor: Chen YC; Department of Nuclear Medicine, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, 362000, China. fudanzhsh@ymail.com.; Medical College, Huaqiao University, South Anji Road 1028#, Fengze District, Quanzhou, 362000, China. fudanzhsh@ymail.com., Wang QQ; Department of Nuclear Medicine, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, 362000, China., Wang YH; Department of Nuclear Medicine, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, 362000, China., Zhuo HL; Department of Cardiology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, 362000, China., Dai RZ; Department of Cardiology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, 362000, China.
Jazyk: angličtina
Zdroj: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology [J Nucl Cardiol] 2022 Feb; Vol. 29 (1), pp. 239-247. Date of Electronic Publication: 2020 Jun 12.
DOI: 10.1007/s12350-020-02219-9
Abstrakt: Background: An open-label, single-center, randomized controlled prospective trial was performed to assess the efficiency and safety of an insulin loading procedure to obtain high-quality cardiac 18 F-FDG PET/CT images for patients with coronary artery disease (CAD).
Methods: Between November 22, 2018 and August 15, 2019, 60 patients with CAD scheduled for cardiac 18 F-FDG PET/CT imaging in our department were randomly allocated in a 1:1 ratio to receive an insulin or standardized glucose loading procedure for cardiac 18 F-FDG imaging. The primary outcome was the ratio of interpretable images (high-quality images defined as myocardium-to-liver ratios ≥ 1). The secondary outcome was the patient preparation time (time interval between administration of insulin/glucose and 18 F-FDG injection). Hypoglycemia events were recorded.
Results: The ratio of interpretable cardiac PET images in the insulin loading group surpassed the glucose loading group (30/30 vs. 25/30, P = 0.026). Preparation time was 71±2 min shorter for the insulin loading group than for the glucose loading group (P < 0.01). Two and six hypoglycemia cases occurred in the insulin and glucose loading groups, respectively.
Conclusion: The insulin loading protocol was a quicker, more efficient, and safer preparation for gaining high-quality cardiac 18 F-FDG images.
(© 2020. American Society of Nuclear Cardiology.)
Databáze: MEDLINE
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