Fatty acids in the de novo lipogenesis pathway and incidence of type 2 diabetes: A pooled analysis of prospective cohort studies.

Autor:	Imamura F; MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom., Fretts AM; Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America., Marklund M; Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden.; The George Institute for Global Health, the Faculty of Medicine, University of New South Wales, Sydney, Australia.; Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, United States of America., Ardisson Korat AV; Department of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America., Yang WS; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei City, the Republic of China., Lankinen M; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland., Qureshi W; Section of Cardiovascular Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America., Helmer C; INSERM, UMR 1219, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France., Chen TA; USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America., Virtanen JK; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland., Wong K; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia., Bassett JK; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia., Murphy R; Centre of Excellence in Cancer Prevention, School of Population & Public Health, Faculty of Medicine, The University of British Columbia, Vancouver, Canada., Tintle N; Department of Mathematics and Statistics, Dordt University, Sioux Center, Iowa, United States of America., Yu CI; Department of Biostatistics, University of Washington School of Public Health, Seattle, Washington, United States of America., Brouwer IA; Department of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, the Netherlands., Chien KL; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei City, the Republic of China., Chen YY; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei City, the Republic of China.; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei City, the Republic of China., Wood AC; USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America., Del Gobbo LC; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, United States of America., Djousse L; Divisions of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America., Geleijnse JM; Division of Human Nutrition and Health, Wageningen University, Wageningen, the Netherlands., Giles GG; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia.; Centre for Epidemiology and Biostatistics, The University of Melbourne, Parkville, Australia.; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Australia., de Goede J; Division of Human Nutrition and Health, Wageningen University, Wageningen, the Netherlands., Gudnason V; Icelandic Heart Association Research Institute, Kopavogur, Iceland., Harris WS; Department of Internal Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, South Dakota, United States of America.; OmegaQuant Analytics, Sioux Falls, South Dakota, United States of America., Hodge A; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia.; Centre for Epidemiology and Biostatistics, The University of Melbourne, Parkville, Australia., Hu F; Department of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America., Koulman A; MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.; National Institute for Health Research Biomedical Research Centres Core Nutritional Biomarker Laboratory, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom.; National Institute for Health Research Biomedical Research Centres Core Metabolomics and Lipidomics Laboratory, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom.; Medical Research Council Elsie Widdowson Laboratory, Cambridge, United Kingdom., Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.; Department of Medicine, Kuopio University Hospital, Kuopio, Finland., Lind L; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Lin HJ; Department of Internal Medicine, National Taiwan University Hospital, Taipei City, the Republic of China., McKnight B; Department of Biostatistics, University of Washington School of Public Health, Seattle, Washington, United States of America., Rajaobelina K; INSERM, UMR 1219, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France., Riserus U; Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden., Robinson JG; Preventive Intervention Center, Departments of Epidemiology, the University of Iowa College of Public Health, Iowa City, Iowa, United States of America., Samieri C; INSERM, UMR 1219, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France., Senn M; USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America., Siscovick DS; The New York Academy of Medicine, New York, New York, United States of America., Soedamah-Muthu SS; Division of Human Nutrition and Health, Wageningen University, Wageningen, the Netherlands.; Center of Research on Psychological and Somatic disorders, Department of Medical and Clinical Psychology, Tilburg University, Tilburg, the Netherlands.; Institute for Food, Nutrition and Health, University of Reading, Reading, United Kingdom., Sotoodehnia N; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America., Sun Q; Department of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America., Tsai MY; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, United States of America., Tuomainen TP; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland., Uusitupa M; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland., Wagenknecht LE; Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America., Wareham NJ; MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom., Wu JHY; The George Institute for Global Health, the Faculty of Medicine, University of New South Wales, Sydney, Australia., Micha R; Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, United States of America., Lemaitre RN; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America., Mozaffarian D; Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, United States of America., Forouhi NG; MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.
Jazyk:	angličtina
Zdroj:	PLoS medicine [PLoS Med] 2020 Jun 12; Vol. 17 (6), pp. e1003102. Date of Electronic Publication: 2020 Jun 12 (Print Publication: 2020).
DOI:	10.1371/journal.pmed.1003102
Abstrakt:	Background: De novo lipogenesis (DNL) is the primary metabolic pathway synthesizing fatty acids from carbohydrates, protein, or alcohol. Our aim was to examine associations of in vivo levels of selected fatty acids (16:0, 16:1n7, 18:0, 18:1n9) in DNL with incidence of type 2 diabetes (T2D). Methods and Findings: Seventeen cohorts from 12 countries (7 from Europe, 7 from the United States, 1 from Australia, 1 from Taiwan; baseline years = 1970-1973 to 2006-2010) conducted harmonized individual-level analyses of associations of DNL-related fatty acids with incident T2D. In total, we evaluated 65,225 participants (mean ages = 52.3-75.5 years; % women = 20.4%-62.3% in 12 cohorts recruiting both sexes) and 15,383 incident cases of T2D over the 9-year follow-up on average. Cohort-specific association of each of 16:0, 16:1n7, 18:0, and 18:1n9 with incident T2D was estimated, adjusted for demographic factors, socioeconomic characteristics, alcohol, smoking, physical activity, dyslipidemia, hypertension, menopausal status, and adiposity. Cohort-specific associations were meta-analyzed with an inverse-variance-weighted approach. Each of the 4 fatty acids positively related to incident T2D. Relative risks (RRs) per cohort-specific range between midpoints of the top and bottom quintiles of fatty acid concentrations were 1.53 (1.41-1.66; p < 0.001) for 16:0, 1.40 (1.33-1.48; p < 0.001) for 16:1n-7, 1.14 (1.05-1.22; p = 0.001) for 18:0, and 1.16 (1.07-1.25; p < 0.001) for 18:1n9. Heterogeneity was seen across cohorts (I2 = 51.1%-73.1% for each fatty acid) but not explained by lipid fractions and global geographical regions. Further adjusted for triglycerides (and 16:0 when appropriate) to evaluate associations independent of overall DNL, the associations remained significant for 16:0, 16:1n7, and 18:0 but were attenuated for 18:1n9 (RR = 1.03, 95% confidence interval (CI) = 0.94-1.13). These findings had limitations in potential reverse causation and residual confounding by imprecisely measured or unmeasured factors. Conclusions: Concentrations of fatty acids in the DNL were positively associated with T2D incidence. Our findings support further work to investigate a possible role of DNL and individual fatty acids in the development of T2D. Competing Interests: I have read the journal's policy and the authors of this manuscript have the following competing interests: JYW and RM report research support from Unilever for other projects on fatty acid biomarkers. LCDG reported receiving ad hoc consulting fees from the Life Sciences Research Organization. CH reported receiving fees for a conference from Novartis. IAB reported involvement in a research project partly funded by Unilever. JGR received research grants from Amarin and Astra-Zeneca. DM reported receiving ad hoc honoraria from Bunge, Pollock Institute, and Quaker Oats; ad hoc consulting for Foodminds, Life Sciences Research Organization, Nutrition Impact, Amarin, AstraZeneca, Winston, and Strawn LLP; membership in Unilever North America Scientific Advisory Board; and chapter royalties from UpToDate. SSSM reported receiving an international award and unrestricted grants for meta-analysis work on dairy foods and cardiometabolic diseases from Global and Dutch Dairy Associations. Other authors do not have any conflict of interest to declare.
Databáze:	MEDLINE
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