Chemical profiles, pharmacological properties, and in silico studies provide new insights on Cycas pectinata .
| Autor: | Tareq AM; Department of Pharmacy, International Islamic University Chittagong, Kumira, Chittagong 4318, Bangladesh.; Society for Interdisciplinary Research and Innovation, Chawkbazar, 4203, Chittagong, Bangladesh., Farhad S; Department of Pharmacy, International Islamic University Chittagong, Kumira, Chittagong 4318, Bangladesh., Neshar Uddin ABM; Department of Pharmacy, International Islamic University Chittagong, Kumira, Chittagong 4318, Bangladesh., Hoque M; Department of Pharmacy, International Islamic University Chittagong, Kumira, Chittagong 4318, Bangladesh., Nasrin MS; Department of Pharmacy, International Islamic University Chittagong, Kumira, Chittagong 4318, Bangladesh.; Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh., Uddin MMR; Department of Pharmacy, International Islamic University Chittagong, Kumira, Chittagong 4318, Bangladesh., Hasan M; Department of Pharmacy, International Islamic University Chittagong, Kumira, Chittagong 4318, Bangladesh., Sultana A; Department of Pharmacy, International Islamic University Chittagong, Kumira, Chittagong 4318, Bangladesh., Munira MS; Department of Pharmacy, Southeast University, Dhaka 1212, Bangladesh., Lyzu C; Biomedical and Toxicological Research Institute, Bangladesh Council of Scientific and Industrial Research (BCSIR), Dr. Qudrat-I-Khuda Road, Dhanmondi, Dhaka 1205, Bangladesh., Moazzem Hossen SM; Department of Pharmacy, Faculty of Biological Science, University of Chittagong, Chittagong 4331, Bangladesh., Ali Reza ASM; Department of Pharmacy, International Islamic University Chittagong, Kumira, Chittagong 4318, Bangladesh.; Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh., Emran TB; Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh. |
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| Jazyk: | angličtina |
| Zdroj: | Heliyon [Heliyon] 2020 Jun 04; Vol. 6 (6), pp. e04061. Date of Electronic Publication: 2020 Jun 04 (Print Publication: 2020). |
| DOI: | 10.1016/j.heliyon.2020.e04061 |
| Abstrakt: | The current study aimed to qualitatively and quantitatively determine the phytochemical components of Cycas pectinata methanol extract (MECP), along with its antioxidant, anti-inflammatory, thrombolytic, locomotor, anxiolytic, analgesic, and antidiarrheal activities. The in vitro antioxidant activity was evaluated by DPPH scavenging assay and the total phenol and total flavonoid contents, while the anti-inflammatory activity was evaluated by a protein denaturation assay. The in vivo locomotor effects were examined using the open field test and hole-cross test. The anxiolytic effect was examined using the elevated plus maze (EPM) test, hole-board test (HBT), and light-dark test (LDT), while the analgesic activity was investigated using the acetic acid-induced writhing test. The antidiarrheal effect was evaluated by castor oil-induced diarrhea and gastrointestinal motility. Ten bioactive compounds were selected on the basis of their biological activities and further investigated using in silico molecular docking simulation to correlate with the identified pharmacological properties. Additionally, the ADME properties of the compounds were evaluated according to their drug-likeness profile. MECP had a maximum total phenol content of 209.85 ± 3.40 gallic acid equivalents/g extract and a total flavonoid content of 105.17 ± 3.45 quercetin equivalents/g extract, with an IC (© 2020 The Author(s).) |
| Databáze: | MEDLINE |
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