Comparative Evaluation of Bone Repair with Four Different Bone Substitutes in Critical Size Defects.

Autor: Grossi-Oliveira G; Oral and Maxillofacial Surgery, Diagnostic and Surgery, Aracatuba School of Dentistry, Sao Paulo State University (UNESP), Aracatuba, Sao Paulo, Brazil., Faverani LP; Oral and Maxillofacial Surgery, Diagnostic and Surgery, Aracatuba School of Dentistry, Sao Paulo State University (UNESP), Aracatuba, Sao Paulo, Brazil., Mendes BC; Oral and Maxillofacial Surgery, Diagnostic and Surgery, Aracatuba School of Dentistry, Sao Paulo State University (UNESP), Aracatuba, Sao Paulo, Brazil., Braga Polo TO; Oral and Maxillofacial Surgery, Diagnostic and Surgery, Aracatuba School of Dentistry, Sao Paulo State University (UNESP), Aracatuba, Sao Paulo, Brazil., Batista Mendes GC; Oral and Maxillofacial Surgery, Department of Oral Surgery, University of Sagrado Coracao, Bauru, Sao Paulo, Brazil., de Lima VN; Oral and Maxillofacial Surgery, Diagnostic and Surgery, Aracatuba School of Dentistry, Sao Paulo State University (UNESP), Aracatuba, Sao Paulo, Brazil., Ribeiro Júnior PD; Oral and Maxillofacial Surgery, Department of Oral Surgery, University of Sagrado Coracao, Bauru, Sao Paulo, Brazil., Okamoto R; Human Anatomy, Department of Basic Sciences, Aracatuba School of Dentistry, Sao Paulo State University (UNESP), Aracatuba, Sao Paulo, Brazil., Magro-Filho O; Oral and Maxillofacial Surgery, Diagnostic and Surgery, Aracatuba School of Dentistry, Sao Paulo State University (UNESP), Aracatuba, Sao Paulo, Brazil.
Jazyk: angličtina
Zdroj: International journal of biomaterials [Int J Biomater] 2020 May 23; Vol. 2020, pp. 5182845. Date of Electronic Publication: 2020 May 23 (Print Publication: 2020).
DOI: 10.1155/2020/5182845
Abstrakt: This study evaluated the osteoconductive potential of four biomaterials used to fill bone defects. For this, 24 male Albino rabbits were submitted to the creation of a bilateral 8 mm calvarial bone defect. The animals were divided into four groups-bovine hydroxyapatite, Bio-Oss® (BIO); Lumina-Bone Porous® (LBP); Bonefill® (BFL); and an alloplastic material, Clonos® (CLN)-and were euthanized at 14 and 40 days. The samples were subjected to histological and histometric analysis for newly formed bone area. Immunohistochemical analysis for Runt-related transcription factor 2 (Runx2), vascular endothelial growth factor (VEGF), and osteocalcin (OC) was performed. After statistical analysis, the CLN group showed greater new bone formation (NB) in both periods analyzed ( p < 0.05). At 14 days, the NB showed greater values in BIO in relation to LBP and BFL groups; however, after 40 days, the LBP group surpassed the results of BIO ( p < 0.001). The immunostaining showed a decrease in Runx2 intensity in BIO after 40 days, while it increased for LBP ( p < 0.05). The CLN showed increased OC compared to the other groups in both periods analyzed ( p < 0.05). Therefore, CLN showed the best osteoconductive behavior in critical defects in rabbit calvaria, and BFL showed the lowest osteoconductive property.
Competing Interests: The authors declare no conflicts of interest.
(Copyright © 2020 Gustavo Grossi-Oliveira et al.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje