Norovirus infection causes acute self-resolving diarrhea in wild-type neonatal mice.

Autor:	Roth AN; Department of Molecular Genetics & Microbiology, College of Medicine, University of Florida, Gainesville, FL, USA., Helm EW; Department of Molecular Genetics & Microbiology, College of Medicine, University of Florida, Gainesville, FL, USA., Mirabelli C; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA., Kirsche E; Department of Molecular Genetics & Microbiology, College of Medicine, University of Florida, Gainesville, FL, USA., Smith JC; Department of Molecular Genetics & Microbiology, College of Medicine, University of Florida, Gainesville, FL, USA., Eurell LB; Office of Research, College of Medicine, University of Florida, Gainesville, FL, USA., Ghosh S; Laboratory of Host-Pathogen Dynamics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Altan-Bonnet N; Laboratory of Host-Pathogen Dynamics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Wobus CE; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA., Karst SM; Department of Molecular Genetics & Microbiology, College of Medicine, University of Florida, Gainesville, FL, USA. skarst@ufl.edu.
Jazyk:	angličtina
Zdroj:	Nature communications [Nat Commun] 2020 Jun 11; Vol. 11 (1), pp. 2968. Date of Electronic Publication: 2020 Jun 11.
DOI:	10.1038/s41467-020-16798-1
Abstrakt:	Human noroviruses are the leading cause of severe childhood diarrhea worldwide, yet we know little about their pathogenic mechanisms. Murine noroviruses cause diarrhea in interferon-deficient adult mice but these hosts also develop systemic pathology and lethality, reducing confidence in the translatability of findings to human norovirus disease. Herein we report that a murine norovirus causes self-resolving diarrhea in the absence of systemic disease in wild-type neonatal mice, thus mirroring the key features of human norovirus disease and representing a norovirus small animal disease model in wild-type mice. Intriguingly, lymphocytes are critical for controlling acute norovirus replication while simultaneously contributing to disease severity, likely reflecting their dual role as targets of viral infection and key components of the host response.
Databáze:	MEDLINE
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