Transcatheter Mitral Repair for Functional Mitral Regurgitation According to Left Ventricular Function: A Real-Life Propensity-Score Matched Study.

Autor: Pascual I; Heart Area, Asturias Central University Hospital, University of Oviedo, Instituto Investigación Sanitaria Principado de Asturias (ISPA), 33011 Oviedo, Spain., Carrasco-Chinchilla F; Cardiology Department, Virgen de la Victoria University Hospital, Instituto de Investigación Biomédica de Málaga (IBIMA), University of Málaga, CIBERCV, 29010 Málaga, Spain., Benito-Gonzalez T; Cardiology Department. University Hospital of León, 24008 León, Spain., Li CH; Cardiology Department, Santa Creu i Sant Pau Hospital, 08041 Barcelona, Spain., Avanzas P; Heart Area, Asturias Central University Hospital, University of Oviedo, Instituto Investigación Sanitaria Principado de Asturias (ISPA), 33011 Oviedo, Spain., Nombela-Franco L; Cardiovascular Institute, Hospital Clínico San Carlos, IdISSC, 28040 Madrid, Spain., Pan M; Cardiology Department, Reina Sofía University Hospital, University of Córdoba (IMIBIC), 14004 Córdoba, Spain., Serrador Frutos A; CIBERCV, Cardiology Department, Hospital Clínico Universitario de Valladolid, 47003 Valladolid, Spain., Freixa X; Cardiology Department, Institut Clínic Cardiovascular, Hospital Clinic de Barcelona, 08036 Barcelona, Spain., Trillo-Nouche R; Cardiology Department, Complejo Hospitalario Universitario de Santiago de Compostela, CIBERCV, 15706 Santiago de Compostela, Spain., Hernández-Antolín RA; Cardiology Department, Ramon y Cajal University Hospital, 28034 Madrid, Spain., Andraka Ikazuriaga L; Cardiology Department, Hospital Universitario de Basurto, 48013 Bilbao, Spain., Cruz-Gonzalez I; Cardiology Department, University Hospital of Salamanca, IBSAL, Institute of Biomedical Research of Salamanca, University of Salamanca, CIBERCV, 37007 Salamanca, Spain., López-Mínguez JR; Cardiology Department, University Hospital of Badajoz, 06080 Badajoz, Spain., Diez JL; Cardiology Department, Hospital Universitario y Politécnico La Fe, 46026 Valencia, Spain., Berenguer-Jofresa A; Cardiology Department, Hospital General Universitario de Valencia, 46014 Valencia, Spain., Sanchis J; Cardiology Department, University Clinic Hospital of Valencia, University of Valencia, INCLIVA, CIBERCV, 46010 Valencia, Spain., Ruiz-Quevedo V; Cardiology Department, Complejo Hospitalario de Navarra, 31008 Pamplona, Spain., Urbano-Carrillo C; Cardiology Department., Complejo Hospital Regional Universitario de Málaga, 29010 Málaga, Spain., Dominguez JFO; Cardiology Department, University Hospital Puerta de Hierro/Majadahonda, 28222 Madrid, Spain., Ortas-Nadal MR; Cardiology Department, University Hospital Miguel Servet, 50009 Zaragoza, Spain., Molina Navarro E; Cardiology Department, University Hospital Virgen de las Nieves, 18014 Granada, Spain., Carrillo X; Cardiology Department, Hospital Universitari Germans Trias i Pujol, 08916 Barcelona, Spain., Alonso-Briales JH; Cardiology Department, Virgen de la Victoria University Hospital, Instituto de Investigación Biomédica de Málaga (IBIMA), University of Málaga, CIBERCV, 29010 Málaga, Spain., Fernández-Vázquez F; Cardiology Department. University Hospital of León, 24008 León, Spain., Asmarats Serra L; Cardiology Department, Santa Creu i Sant Pau Hospital, 08041 Barcelona, Spain., Hernandez-Vaquero D; Heart Area, Asturias Central University Hospital, University of Oviedo, Instituto Investigación Sanitaria Principado de Asturias (ISPA), 33011 Oviedo, Spain., Jimenez-Quevedo P; Cardiovascular Institute, Hospital Clínico San Carlos, IdISSC, 28040 Madrid, Spain., Mesa D; Cardiology Department, Reina Sofía University Hospital, University of Córdoba (IMIBIC), 14004 Córdoba, Spain., Rodríguez-Gabella T; CIBERCV, Cardiology Department, Hospital Clínico Universitario de Valladolid, 47003 Valladolid, Spain., Regueiro A; Cardiology Department, Institut Clínic Cardiovascular, Hospital Clinic de Barcelona, 08036 Barcelona, Spain., Martinez Monzonís A; Cardiology Department, Complejo Hospitalario Universitario de Santiago de Compostela, CIBERCV, 15706 Santiago de Compostela, Spain., Salido Tahoces L; Cardiology Department, Ramon y Cajal University Hospital, 28034 Madrid, Spain., Ruiz Gomez L; Cardiology Department, Hospital Universitario de Basurto, 48013 Bilbao, Spain., Trejo-Velasco B; Cardiology Department, University Hospital of Salamanca, IBSAL, Institute of Biomedical Research of Salamanca, University of Salamanca, CIBERCV, 37007 Salamanca, Spain., Becerra-Muñoz VM; Cardiology Department, Virgen de la Victoria University Hospital, Instituto de Investigación Biomédica de Málaga (IBIMA), University of Málaga, CIBERCV, 29010 Málaga, Spain., Garrote-Coloma C; Cardiology Department. University Hospital of León, 24008 León, Spain., Fernández Peregrina E; Cardiology Department, Santa Creu i Sant Pau Hospital, 08041 Barcelona, Spain., Lorca R; Heart Area, Asturias Central University Hospital, University of Oviedo, Instituto Investigación Sanitaria Principado de Asturias (ISPA), 33011 Oviedo, Spain., Agustín JA; Cardiovascular Institute, Hospital Clínico San Carlos, IdISSC, 28040 Madrid, Spain., Romero M; Cardiology Department, Reina Sofía University Hospital, University of Córdoba (IMIBIC), 14004 Córdoba, Spain., Amat-Santos IJ; CIBERCV, Cardiology Department, Hospital Clínico Universitario de Valladolid, 47003 Valladolid, Spain., Sabaté M; Cardiology Department, Institut Clínic Cardiovascular, Hospital Clinic de Barcelona, 08036 Barcelona, Spain., Alvarez ABC; Cardiology Department, Complejo Hospitalario Universitario de Santiago de Compostela, CIBERCV, 15706 Santiago de Compostela, Spain., Hernandez-Garcia JM; Cardiology Department, Virgen de la Victoria University Hospital, Instituto de Investigación Biomédica de Málaga (IBIMA), University of Málaga, CIBERCV, 29010 Málaga, Spain., Gualis J; Cardiology Department. University Hospital of León, 24008 León, Spain., Arzamendi D; Cardiology Department, Santa Creu i Sant Pau Hospital, 08041 Barcelona, Spain., Moris C; Heart Area, Asturias Central University Hospital, University of Oviedo, Instituto Investigación Sanitaria Principado de Asturias (ISPA), 33011 Oviedo, Spain., Tirado-Conte G; Cardiovascular Institute, Hospital Clínico San Carlos, IdISSC, 28040 Madrid, Spain., Sánchez-Recalde A; Cardiology Department, Ramon y Cajal University Hospital, 28034 Madrid, Spain., Estevez-Loureiro R; Cardiology Department, Alvaro Cunqueiro University Hospital, 36213 Vigo, Spain.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2020 Jun 09; Vol. 9 (6). Date of Electronic Publication: 2020 Jun 09.
DOI: 10.3390/jcm9061792
Abstrakt: Background: Transcatheter mitral valve repair (TMVR) could improve survival in functional mitral regurgitation (FMR), but it is necessary to consider the influence of left ventricular ejection fraction (LVEF). Therefore, we compare the outcomes after TMVR with Mitraclip ® between two groups according to LVEF.
Methods: In an observational registry study, we compared the outcomes in patients with FMR who underwent TMVR with and without LVEF <30%. The primary endpoint was the combined one-year all-cause mortality and unplanned hospital readmissions due to HF. The secondary end-points were New York Heart Association (NYHA) functional class and mitral regurgitation (MR) severity. Propensity-score matching was used to create two groups with the same baseline characteristics, except for baseline LVEF.
Results: Among 535 FMR eligible patients, 144 patients with LVEF <30% (group 1) and 144 with LVEF >30% (group 2) had similar propensity scores and were included in the analyses. The primary study endpoint was significantlly higher in group 1 (33.3% vs. 9.4%, p = 0.002). There was a maintained improvement in secondary endpoints without significant differences among groups.
Conclusion: FMR patients with LVEF <30% treated with MitraClip ® had higher mortality and readmissions than patients with LVEF ≥30% treated with the same device. However, both groups improved the NYHA functional class and MR severity.
Databáze: MEDLINE
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