Associations between intrauterine exposure to polychlorinated biphenyls on neonatal ano-genital distance.

Autor: Sheinberg R; Clinical Pharmacology and Toxicology Unit, Shamir (Assaf Harofeh) Medical Center, Zerifin, Israel. Electronic address: Revitalsh@shamir.gov.il., Siegel EL; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, United States., Keidar R; Department of Neonatology, Shamir (Assaf Harofeh) Medical Center, Zerifin, Israel., Mandel D; Department of Neonatology, Dana Children's Hospital, Tel-Aviv Medical Center, Tel-Aviv, Israel., Lubetzky R; Department of Neonatology, Dana Children's Hospital, Tel-Aviv Medical Center, Tel-Aviv, Israel., Kohn E; Clinical Pharmacology and Toxicology Unit, Shamir (Assaf Harofeh) Medical Center, Zerifin, Israel., Livneh A; Department of Neonatology, Shamir (Assaf Harofeh) Medical Center, Zerifin, Israel., Tovbin J; Obstetrics and Gynecology Division, Shamir (Assaf Harofeh) Medical Center, Zerifin, Israel., Betser M; Obstetrics and Gynecology Division, Shamir (Assaf Harofeh) Medical Center, Zerifin, Israel., Moskovich M; Obstetrics and Gynecology Division, Shamir (Assaf Harofeh) Medical Center, Zerifin, Israel., Marom R; Department of Neonatology, Dana Children's Hospital, Tel-Aviv Medical Center, Tel-Aviv, Israel., Ovental A; Department of Neonatology, Dana Children's Hospital, Tel-Aviv Medical Center, Tel-Aviv, Israel., Daniel S; Department of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel., Factor-Litvak P; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, United States., Berkovitch M; Clinical Pharmacology and Toxicology Unit, Shamir (Assaf Harofeh) Medical Center, Zerifin, Israel., Levy A; Department of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Jazyk: angličtina
Zdroj: Reproductive toxicology (Elmsford, N.Y.) [Reprod Toxicol] 2020 Sep; Vol. 96, pp. 67-75. Date of Electronic Publication: 2020 Jun 08.
DOI: 10.1016/j.reprotox.2020.06.005
Abstrakt: Polychlorinated Biphenyls (PCBs) are widespread environmental contaminants. PCBs have endocrine disrupting properties which raises concerns regarding their effect on the developing fetus. This study aimed to examine the association between prenatal exposure to PCBs and anogenital distance (AGD) in newborns. Serum concentrations of PCB congeners -118, -138, -153 and -180 were measured in 175 pregnant women presenting to the delivery room. AGD was measured in their newborns. Regression models were used to estimate associations between maternal PCB exposure and infant anogenital measurements, controlling for possible confounding variables. Mean maternal serum concentrations were 2.95 ± 2.18 ng/g, 4.62 ± 3.54 ng/g, 7.67 ± 6.42 ng/g and 5.10 ± 3.91 ng/g for congeners -118, -138, -153 and -180, respectively. Higher maternal concentrations of PCBs were associated with reduced AGD measures in male infants. Higher maternal concentrations of PCB-138 and PCB-153 were associated with reduced ano-scrotal distances and higher maternal concentrations of all four PCB congeners were associated with reduced ano-penile distances. No significant associations were found between any PCB congener and any AGD measure in female newborns. This study demonstrates that intrauterine exposure to PCBs may be associated with reduced AGD in male newborns. More research is needed to reveal the implications for adult reproductive health.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: