Vitamin D, Folate, and Cobalamin Serum Concentrations Are Related to Brain Volume and White Matter Integrity in Urban Adults.

Autor: Beydoun MA; Laboratory of Epidemiology and Population Sciences, The National Institute on Aging (NIA) The Intramural Research Program (IRP), The National Institutes of Health (NIH), Baltimore, MD, United States., Shaked D; Laboratory of Epidemiology and Population Sciences, The National Institute on Aging (NIA) The Intramural Research Program (IRP), The National Institutes of Health (NIH), Baltimore, MD, United States.; Department of Psychology, University of Maryland, Baltimore County, MD, United States., Hossain S; Laboratory of Epidemiology and Population Sciences, The National Institute on Aging (NIA) The Intramural Research Program (IRP), The National Institutes of Health (NIH), Baltimore, MD, United States., Beydoun HA; Department of Research Programs, Fort Belvoir Community Hospital, Fort Belvoir, VA, United States., Katzel LI; Geriatric Research Education and Clinical Center, Baltimore VA Medical Center, Baltimore, MD, United States.; Division of Gerontology & Geriatric Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, United States., Davatzikos C; Section for Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States., Gullapalli RP; Department of Diagnostic Radiology, University of Maryland School of Medicine, Baltimore, MD, United States., Seliger SL; Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, United States., Erus G; Section for Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States., Evans MK; Laboratory of Epidemiology and Population Sciences, The National Institute on Aging (NIA) The Intramural Research Program (IRP), The National Institutes of Health (NIH), Baltimore, MD, United States., Zonderman AB; Laboratory of Epidemiology and Population Sciences, The National Institute on Aging (NIA) The Intramural Research Program (IRP), The National Institutes of Health (NIH), Baltimore, MD, United States., Waldstein SR; Department of Psychology, University of Maryland, Baltimore County, MD, United States.; Geriatric Research Education and Clinical Center, Baltimore VA Medical Center, Baltimore, MD, United States.; Division of Gerontology & Geriatric Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, United States.
Jazyk: angličtina
Zdroj: Frontiers in aging neuroscience [Front Aging Neurosci] 2020 May 25; Vol. 12, pp. 140. Date of Electronic Publication: 2020 May 25 (Print Publication: 2020).
DOI: 10.3389/fnagi.2020.00140
Abstrakt: Background and objectives: Lower vitamin status has been linked to cognitive deficits, pending mechanistic elucidation. Serum 25-hydroxyvitamin D [25(OH)D], folate and cobalamin were explored against brain volumes and white matter integrity (WMI). Methods: Three prospective waves from Healthy Aging in Neighborhoods of Diversity Across the Life Span (HANDLS) study were used [Baltimore, City, MD, 2004-2015, N = 183-240 urban adults (Age v1 : 30-64 years)]. Serum vitamin 25-hydroxyvitamin D [25(OH)D], folate and cobalamin concentrations were measured at visits 1 (v 1 : 2004-2009) and 2 (v 2 : 2009-2013), while structural and diffusion Magnetic Resonance Imaging (sMRI/dMRI) outcomes were measured at v scan : 2011-2015. Top 10 ranked adjusted associations were corrected for multiple testing using familywise Bonferroni (FWER <0.05) and false discovery rates (FDR, q -value < 0.10). Results: We found statistically significant (FWER < 0.05; β±SE) direct associations of 25(OH)D(v 1 ) with WM volumes [overall: +910 ± 336/males: +2,054 ± 599], occipital WM; [overall: +140 ± 40, males: +261 ± 67 and Age v1 > 50 years: +205 ± 54]; parietal WM; [overall: +251 ± 77, males: +486 ± 129 and Age v1 > 50 years: +393 ± 108] and left occipital pole volume [overall: +15.70 ± 3.83 and above poverty: 19.0 ± 4.3], findings replicated for 25(OH)D (v 2 -v 1 ) annualized exposure, which was also linked with greater WMI (fractional anisotropy, FA) in the anterior limb of the internal capsule (ALIC); FWER < 0.05 [Overall: +0.0020 ± 0.0004; Whites: +0.0024 ± 0.0004] and in the cingulum (hippocampus) [Overall: +0.0016 ± 0.0004]. Only trends were detected for cobalamin exposures ( q < 0.10), while serum folate (v 1 ) was associated with lower mean diffusivity (MD) in ALIC, reflecting greater WMI, overall. Conclusions: Among urban adults, serum 25(OH)D status and increase were consistently linked to larger occipital and parietal WM volumes and greater region-specific WMI. Pending longitudinal replication of our findings, randomized controlled trials of vitamin D supplementation should be conducted against brain marker outcomes.
(Copyright © 2020 Beydoun, Shaked, Hossain, Beydoun, Katzel, Davatzikos, Gullapalli, Seliger, Erus, Evans, Zonderman and Waldstein.)
Databáze: MEDLINE
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