Description of an atypical Toxoplasma gondii isolate from a case of congenital toxoplasmosis in northeastern Brazil.

Autor: de Melo RPB; Department of Veterinary Medicine, Laboratory of Infectious-Contagious Diseases of Domestic Animals, Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros, Dois Irmãos, Recife, Pernambuco, 52171-900, Brazil. renatapbm@gmail.com., Wanderley FS; Laboratory of Parasitic Infectious Diseases, Universidade Estadual de Ciências da Saúde de Alagoas, Rua Jorge de Lima, 113, Trapiche da Barra, Maceió, Alagoas, 57010382, Brazil., Porto WJN; Biological and Health Science Institute, Universidade Federal de Alagoas, Av. Lourival Melo Mota, Tabuleiro do Martins, Maceió, Alagoas, 57072-900, Brazil., Pedrosa CM; Viçosa Educacional Unit, Universidade Federal de Alagoas, Av. Firmino Maia, Fazenda São Luiz, Viçosa, Alagoas, 57309-005, Brazil., Hamilton CM; Moredun Research Institute, Pentlands Science Park, Midlothian, Scotland, EH26 0PZ, UK., de Oliveira MHGS; Viçosa Educacional Unit, Universidade Federal de Alagoas, Av. Firmino Maia, Fazenda São Luiz, Viçosa, Alagoas, 57309-005, Brazil., Ribeiro-Andrade M; Department of Veterinary Medicine, Laboratory of Infectious-Contagious Diseases of Domestic Animals, Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros, Dois Irmãos, Recife, Pernambuco, 52171-900, Brazil., Rêgo RCDS; Laboratory of Parasitic Infectious Diseases, Universidade Estadual de Ciências da Saúde de Alagoas, Rua Jorge de Lima, 113, Trapiche da Barra, Maceió, Alagoas, 57010382, Brazil., Katzer F; Moredun Research Institute, Pentlands Science Park, Midlothian, Scotland, EH26 0PZ, UK., Mota RA; Department of Veterinary Medicine, Laboratory of Infectious-Contagious Diseases of Domestic Animals, Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros, Dois Irmãos, Recife, Pernambuco, 52171-900, Brazil.
Jazyk: angličtina
Zdroj: Parasitology research [Parasitol Res] 2020 Aug; Vol. 119 (8), pp. 2727-2731. Date of Electronic Publication: 2020 Jun 10.
DOI: 10.1007/s00436-020-06746-9
Abstrakt: We report a case of severe congenital toxoplasmosis that involved an atypical T. gondii genotype in a newborn baby from Alagoas state in Northeastern Brazil. A pregnant woman presented IgM and IgG anti-T. gondii antibodies, as detected by the chemiluminescence immunoassay on the second trimester of pregnancy. A mouse bioassay was performed using umbilical cord blood and one isolate was obtained. The isolate was designated TgCTBrAL1 and genetic characterization revealed genotype ToxoDB #162. Genotype results of the rhoptry genes, ROP5 and ROP18, could predict the high virulence of the isolate in mice, which was confirmed by an in vivo virulence assay. This is the first report of generating a T. gondii isolate from a newborn baby with congenital toxoplasmosis in Northeastern Brazil.
Databáze: MEDLINE
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