The Quality of Recovery after Dexamethasone, Ondansetron, or Placebo Administration in Patients Undergoing Lower Limbs Orthopedic Surgery under Spinal Anesthesia Using Intrathecal Morphine. A Randomized Controlled Trial.

Autor: Moro ET; Department of Surgery, School of Medical and Health Sciences, Pontifical Catholic University of São Paulo, Sorocaba, São Paulo, Brazil., Ferreira MAT; Department of Surgery, School of Medical and Health Sciences, Pontifical Catholic University of São Paulo, Sorocaba, São Paulo, Brazil., Gonçalves RDS; Department of Surgery, School of Medical and Health Sciences, Pontifical Catholic University of São Paulo, Sorocaba, São Paulo, Brazil., Vargas RC; School of Medical and Health Sciences, Pontifical Catholic University of São Paulo, São Paulo, Brazil., Calil SJ; School of Medical and Health Sciences, Pontifical Catholic University of São Paulo, São Paulo, Brazil., Soranz MA; School of Medical and Health Sciences, Pontifical Catholic University of São Paulo, São Paulo, Brazil., Bloomstone J; University of Arizona College of Medicine-Phoenix, Phoenix, AZ, USA.; Division of Surgery and Interventional Sciences, University College London, London, UK.; Envision Physician Services, Plantation, Florida, USA.
Jazyk: angličtina
Zdroj: Anesthesiology research and practice [Anesthesiol Res Pract] 2020 May 20; Vol. 2020, pp. 9265698. Date of Electronic Publication: 2020 May 20 (Print Publication: 2020).
DOI: 10.1155/2020/9265698
Abstrakt: Intrathecal morphine is widely and successfully used to prevent postoperative pain after orthopedic surgery, but it is frequently associated with side effects. The aim of this study was to evaluate the effect of dexamethasone or ondansetron when compared to placebo to reduce the occurrence of these undesirable effects and, consequently, to improve the quality of recovery based on patient's perspective. Methods . One hundred and thirty-five patients undergoing lower extremity orthopedic surgery under spinal anesthesia using bupivacaine and morphine were randomly assigned to receive IV dexamethasone, ondansetron, or saline. On the morning following surgery, a quality of recovery questionnaire (QoR-40) was completed. Results . No differences were detected in the global and dimensional QoR-40 scores following surgery; however, following postanesthesia care unit (PACU) discharge, pain scores were higher in patients receiving ondansetron compared with patients who received dexamethasone. Conclusion . Neither ondansetron nor dexamethasone improves the quality of recovery after lower limbs orthopedic surgery under spinal anesthesia using intrathecal morphine.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2020 Eduardo Toshiyuki Moro et al.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje