| Autor: |
Waldum HL; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway. |
| Jazyk: |
angličtina |
| Zdroj: |
Scandinavian journal of gastroenterology [Scand J Gastroenterol] 2020 Jun; Vol. 55 (6), pp. 752-758. Date of Electronic Publication: 2020 Jun 09. |
| DOI: |
10.1080/00365521.2020.1771758 |
| Abstrakt: |
Studies on the regulation of gastric acid secretion started more than 100 years ago at an early phase of experimental physiology. In nearly the whole last century there were disputes about the interpretation of the findings: the interaction between the three principle gastric acid secretagogues acetylcholine, gastrin and histamine, the cell producing the relevant histamine which turned out to be the ECL cell, the ability of the ECL cell to divide and thus develop into tumours, the classification of gastric carcinomas and the mechanism for Helicobacter pylori carcinogenesis. The elucidation of the central role of the ECL cell and thus its main regulator, gastrin, solve all these controversies, and gives a solid base for handling upper gastrointestinal diseases. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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