Long-Term Changes in Sleep Disordered Breathing in Renal Transplant Patients: Relevance of the BMI.

Autor: Mallamaci F; CNR-IFC Clinical Epidemiology of Renal Diseases and Hypertension Unit, Center of Clinical Physiology, National Research Council of Italy, Reggio Cal., c/o Ospedali Riuniti, 89124 Reggio Calabaria, Italy.; Department of Medicine, Division of Nephrology and Transplantation, Ospedali Riuniti, 89124 Reggio Calabria, Italy., Tripepi R; CNR-IFC Clinical Epidemiology of Renal Diseases and Hypertension Unit, Center of Clinical Physiology, National Research Council of Italy, Reggio Cal., c/o Ospedali Riuniti, 89124 Reggio Calabaria, Italy., D'Arrigo G; CNR-IFC Clinical Epidemiology of Renal Diseases and Hypertension Unit, Center of Clinical Physiology, National Research Council of Italy, Reggio Cal., c/o Ospedali Riuniti, 89124 Reggio Calabaria, Italy., Porto G; CNR-IFC Clinical Epidemiology of Renal Diseases and Hypertension Unit, Center of Clinical Physiology, National Research Council of Italy, Reggio Cal., c/o Ospedali Riuniti, 89124 Reggio Calabaria, Italy., Versace MC; CNR-IFC Clinical Epidemiology of Renal Diseases and Hypertension Unit, Center of Clinical Physiology, National Research Council of Italy, Reggio Cal., c/o Ospedali Riuniti, 89124 Reggio Calabaria, Italy., Marino C; CNR-IFC Clinical Epidemiology of Renal Diseases and Hypertension Unit, Center of Clinical Physiology, National Research Council of Italy, Reggio Cal., c/o Ospedali Riuniti, 89124 Reggio Calabaria, Italy., Sanguedolce MC; CNR-IFC Clinical Epidemiology of Renal Diseases and Hypertension Unit, Center of Clinical Physiology, National Research Council of Italy, Reggio Cal., c/o Ospedali Riuniti, 89124 Reggio Calabaria, Italy., Tripepi G; CNR-IFC Clinical Epidemiology of Renal Diseases and Hypertension Unit, Center of Clinical Physiology, National Research Council of Italy, Reggio Cal., c/o Ospedali Riuniti, 89124 Reggio Calabaria, Italy., Zoccali C; CNR-IFC Clinical Epidemiology of Renal Diseases and Hypertension Unit, Center of Clinical Physiology, National Research Council of Italy, Reggio Cal., c/o Ospedali Riuniti, 89124 Reggio Calabaria, Italy.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2020 Jun 04; Vol. 9 (6). Date of Electronic Publication: 2020 Jun 04.
DOI: 10.3390/jcm9061739
Abstrakt: Sleep disordered breathing (SDB), as defined by the Apnea Hypopnea Index (AHI), is a highly prevalent disturbance in end stage kidney disease. SDB improves early on after renal transplantation but long-term changes in AHI in these patients have not been studied. We studied the long-term changes in AHI in a series of 221 renal transplant patients (mean age: 47 ± 12 years; 70% males) over a median follow up of 35 months. Data analysis was made by the generalized estimating equations method (GEE). On longitudinal observation, the median AHI rose from 1.8 (Interquartile range: 0.6-5.0) to 2.9 (IQR: 1.0-6.6) and to 3.6 (IQR: 1.7-10.4) at the second and third visit, respectively ( p = 0.009 by the GEE model and the proportion of patients with moderate to severe SDB rose from 8% to 20%. Longitudinal changes in minimum oxygen saturation (minSaO 2 ) mirrored those in the AHI. In adjusted analyses, repeated measurements of BMI ( p < 0.009) emerged as the strongest independent longitudinal correlate of AHI and MinSaO 2 . The AHI worsens over time in renal transplant patients and longitudinal changes of this biomarker are directly related to simultaneous changes in BMI. Overweight/obesity, a potentially modifiable risk factor, is an important factor underlying the risk of SDB in this population.
Databáze: MEDLINE
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