Prevalence, trends and in-hospital outcomes of takotsubo syndrome among United States cannabis users.

Autor: Desai R; Division of Cardiology, Atlanta VA Medical Center, Decatur, GA, USA. Electronic address: drrupakdesai@gmail.com., Desai A; Department of Internal Medicine, University of Connecticut School of Medicine, UCONN Health, Farmington, CT, USA., Fong HK; Division of Cardiology, UC Davis Medical Center, Sacramento, CA, USA., Mahmood A; Department of Internal Medicine, Eastern Idaho Regional Medical Center, Idaho Falls, ID, USA., Shah K; Division of Psychiatry, Griffin Memorial Hospital, Norman, OK, USA., Varakantam VR; Department of Medicine, Medi Citi Institute of Medical Sciences, Medchal Mandal, Ghanapur, Telangana, India., Haque FA; Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Science University, Wardha, Maharashtra, India., Savani S; Public Health, New York University, New York, NY, USA., Gangani K; Department of Internal Medicine, Texas Health Arlington Memorial Hospital, Arlington, TX, USA., Kumar G; Division of Cardiology, Atlanta VA Medical Center, Decatur, GA, USA; Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA., Sachdeva R; Division of Cardiology, Atlanta VA Medical Center, Decatur, GA, USA; Division of Cardiology, Medical College of Georgia, Augusta, GA, USA; Division of Cardiology, Morehouse School of Medicine, Atlanta, GA, USA.
Jazyk: angličtina
Zdroj: International journal of cardiology [Int J Cardiol] 2020 Oct 01; Vol. 316, pp. 43-46. Date of Electronic Publication: 2020 Jun 06.
DOI: 10.1016/j.ijcard.2020.05.088
Abstrakt: Background: Recent reports suggest a link between increased cannabis (marijuana) use and stress-cardiomyopathy (Takotsubo Syndrome, TTS) and related complications. Amidst recent trends in cannabis legalization and a paucity of data, it remains essential to evaluate the prevalence, trends and outcomes of TTS in cannabis users on a large-scale.
Method: We studied prevalence and trends in TTS among adult cannabis users vs. non-users using the National Inpatient Sample (2007-2014). Baseline characteristics, comorbidities, and in-hospital outcomes of TTS were compared between cannabis users vs. non-users. Weighted logistic regression was performed adjusting for confounders to estimate the inpatient outcomes of TTS with vs. without cannabis use.
Results: The overall prevalence of TTS in cannabis users (47/100,000) was lower as compared to non-users (62/100,000). Rising trends in TTS among cannabis users (<11 to 82, ~8-fold) were more pronounced as compared to non-users (19 to 108, ~6 fold) per 100,000 hospitalizations from 2007 to 2014 (p trend <0.001). Of all inpatient encounters for TTS (n=156,506), 1565 (0.1%) reported cannabis use. Polysubstance use including alcohol (4.1% vs. 24.4%), cocaine (0.4% vs. 8.5%), amphetamine (0.2% vs. 8.0%), and smoking (31.2% vs. 64.8%) was significantly higher in TTS-cannabis cohort. Although cardiovascular comorbidities were lower in TTS-cannabis cohort, the adjusted odds of all-cause mortality (aOR1.50, p<.05) were 50% higher in cannabis users compared to non-users without statistically significant difference in cardiac complications.
Conclusions: Cannabis users showed lower prevalence but a more pronounced rising trend of TTS and subsequent risk of in-hospital mortality compared to non-users.
(Copyright © 2020. Published by Elsevier B.V.)
Databáze: MEDLINE
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