Chronic Atrophic Gastritis with Negative Intrinsic Factor and Parietal Cell Antibody Presenting as a Severe Hemolytic Anemia.

Autor: Cittolin-Santos GF; Medical University of South Carolina, Department of Internal Medicine, Charleston, SC, USA., Khalil S; Medical University of South Carolina, Department of Internal Medicine, Charleston, SC, USA., Bakos JK; Medical University of South Carolina, Department of Internal Medicine, Charleston, SC, USA., Baker K; Medical University of South Carolina, Department of Internal Medicine, Charleston, SC, USA.
Jazyk: angličtina
Zdroj: Case reports in hematology [Case Rep Hematol] 2020 May 15; Vol. 2020, pp. 8697493. Date of Electronic Publication: 2020 May 15 (Print Publication: 2020).
DOI: 10.1155/2020/8697493
Abstrakt: A 28-year-old Caucasian male with Hashimoto's disease and vitiligo presented with two weeks of dizziness on exertion following pharyngitis which was treated with prednisone 40 mg by mouth once a day for five days. Initial workup revealed anemia, elevated lactate dehydrogenase (LDH), and low haptoglobin. He underwent workup for causes of hemolytic anemia which was remarkable for a peripheral blood smear with hypersegmented neutrophils and low vitamin B12 levels concerning for pernicious anemia. Parietal cell and intrinsic factor antibodies were negative, and he then underwent an esophagogastroduodenoscopy with biopsy. The biopsy was negative for Helicobacter pylori , and the immunohistochemical stains were suggestive of chronic atrophic gastritis. He was started on vitamin B12 1,000 mcg intramuscular injections daily. His hemoglobin, LDH, and haptoglobin normalized. Given the absence of the parietal cell antibody and intrinsic factor antibody, this is a rare case of seronegative pernicious anemia.
Competing Interests: The authors declare that they have no conflicts of interest to declare.
(Copyright © 2020 G. F. Cittolin-Santos et al.)
Databáze: MEDLINE
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