Could autism spectrum disorders be a risk factor for COVID-19?

Autor: Lima MES; Centro de Ciências da Saúde, Curso de Medicina, Universidade Estadual do Ceará, Fortaleza, Brazil., Barros LCM; Centro de Ciências da Saúde, Curso de Medicina, Universidade Estadual do Ceará, Fortaleza, Brazil., Aragão GF; Centro de Ciências da Saúde, Curso de Medicina, Universidade Estadual do Ceará, Fortaleza, Brazil; Faculdade de Medicina, Núcleo de Pesquisa e Desenvolvimento de Medicamentos, Universisade Federal do Ceará, Fortaleza, Brazil. Electronic address: gislei.frota@uece.br.
Jazyk: angličtina
Zdroj: Medical hypotheses [Med Hypotheses] 2020 Nov; Vol. 144, pp. 109899. Date of Electronic Publication: 2020 May 30.
DOI: 10.1016/j.mehy.2020.109899
Abstrakt: The coronavirus SARS-CoV-2 pandemia is infecting millions of people and some studies relate conditions that might increase the risk of developing a fatal course for the disease, such as diabetes, cardiovascular diseases and obesity. In COVID-19 physiopathology, one of the main inflammation mechanisms is the "cytokine storm", causing a pro-inflammatory state, related to cardiac and pulmonary damage. There is also a less effective role of lymphocyte B and T in the humoral immunity due to the reduction of their proliferative response. The physiopathology of ASD (Autism Spectrum Disorder) involves several modifications at the genetic and at the immune level, such as the increase of inflammatory cytokines and abnormal immune response in several levels. We hypothesize that ASD could be a risk-factor as the other conditions are.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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