Influence of Tumor Suppressor p53 Functioning on the Expression of Antioxidant System Genes under the Action of Cytotoxic Compounds.

Autor: Mumyatova VA; Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow region, Russia. vmumyatova@bk.ru.; Scientific and Educational Center in Chernogolovka of Moscow Region State University, Mytishchi, Moscow region, Russia. vmumyatova@bk.ru., Balakina AA; Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow region, Russia.; Scientific and Educational Center in Chernogolovka of Moscow Region State University, Mytishchi, Moscow region, Russia., Lapshina MA; Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow region, Russia.; Scientific and Educational Center in Chernogolovka of Moscow Region State University, Mytishchi, Moscow region, Russia., Sen' VD; Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow region, Russia., Kornev AB; Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow region, Russia., Terent'ev AA; Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow region, Russia.; M. V. Lomonosov Moscow State University, Moscow, Russia.; Scientific and Educational Center in Chernogolovka of Moscow Region State University, Mytishchi, Moscow region, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2020 May; Vol. 169 (1), pp. 169-175. Date of Electronic Publication: 2020 Jun 05.
DOI: 10.1007/s10517-020-04844-3
Abstrakt: The effect of inhibition of the tumor suppressor p53 on the antioxidant system genes expression under the influence of cytotoxic compounds of the platinum group was studied. It was found that the action of platinum(II) and platinum(IV) complexes induced accumulation of p53 protein with a maximum in 12 h, which was confirmed by an increase in the expression of the P21 gene, the target gene of the p53 protein. It was shown that the action of platinum complexes activated the expression of catalase and superoxide dismutase 2 genes. Suppression of p53 protein functions with specific inhibitor α-piphitrin under the action of platinum complexes reduced the expression of catalase and superoxide dismutase 2 genes and the target gene P21, which attested to the p53-dependent regulation of these genes.
Databáze: MEDLINE
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