Health-related quality of life overview after different curative treatment options in muscle-invasive bladder cancer: an umbrella review.

Autor: Rammant E; Department of Human Structure and Repair, Ghent University, Corneel Heymanslaan 10, 9000, Ghent, Belgium. elke.rammant@ugent.be., Van Wilder L; Department of Public Health and Primary Care, University Hospital, Ghent University, Ghent, Belgium., Van Hemelrijck M; School of Cancer and Pharmaceutical Studies, Translational Oncology & Urology Research (TOUR), King's College London, London, UK., Pauwels NS; The Knowledge Center for Health Ghent, Ghent University, Ghent, Belgium., Decaestecker K; Department of Urology, Ghent University Hospital, Ghent, Belgium., Van Praet C; Department of Urology, Ghent University Hospital, Ghent, Belgium., Bultijnck R; Department of Human Structure and Repair, Ghent University, Corneel Heymanslaan 10, 9000, Ghent, Belgium., Ost P; Department of Human Structure and Repair, Ghent University, Corneel Heymanslaan 10, 9000, Ghent, Belgium.; Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium., Van Vaerenbergh T; Department of Human Structure and Repair, Ghent University, Corneel Heymanslaan 10, 9000, Ghent, Belgium., Verhaeghe S; Department of Public Health and Primary Care, University Centre for Nursing and Midwifery, Ghent University, Ghent, Belgium.; Department of Nursing, VIVES University College, Roeselare, Belgium.; Staff Member Nursing Department, Ghent University Hospital, Ghent, Belgium., Van Hecke A; Department of Public Health and Primary Care, University Centre for Nursing and Midwifery, Ghent University, Ghent, Belgium.; Staff Member Nursing Department, Ghent University Hospital, Ghent, Belgium., Fonteyne V; Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium.
Jazyk: angličtina
Zdroj: Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation [Qual Life Res] 2020 Nov; Vol. 29 (11), pp. 2887-2910. Date of Electronic Publication: 2020 Jun 06.
DOI: 10.1007/s11136-020-02544-z
Abstrakt: Purpose: This umbrella review aims to evaluate the quality, summarize and compare the conclusions of systematic reviews investigating the impact of curative treatment options on health-related quality of life (HRQoL) in muscle-invasive bladder cancer (MIBC).
Methods: The Cochrane Library, MEDLINE, Embase and Web of Science were searched independently by two authors from inception until 06 January 2020. Systematic reviews and meta-analyses assessing the impact of any curative treatment option on HRQol in MIBC patients were eligible. Risk of bias was assessed using the AMSTAR 2 tool.
Results: Thirty-two reviews were included. Robot-assisted RC with extracorporeal urinary diversion and open RC have similar HRQoL (n = 10). Evidence for pelvic organ-sparing RC was too limited (n = 2). Patients with a neobladder showed better overall and physical HRQoL outcomes, but worse urinary function in comparison with ileal conduit (n = 17). Bladder-preserving radiochemotherapy showed slightly better urinary and sexual but worse gastro-intestinal HRQoL outcomes in comparison with RC patients (n = 6). Quality of the reviews was low in more than 50% of the available reviews and most of the studies included in the reviews were nonrandomized studies.
Conclusion: This umbrella review gives a comprehensive overview of the available evidence to date.
Databáze: MEDLINE
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