Comparative Target Analysis of Chlorinated Biphenyl Antimicrobials Highlights MenG as a Molecular Target of Triclocarban.
Autor: | Macsics R; Chair of Organic Chemistry II, Technische Universität München, Garching bei München, Germany., Hackl MW; Chair of Organic Chemistry II, Technische Universität München, Garching bei München, Germany., Fetzer C; Chair of Organic Chemistry II, Technische Universität München, Garching bei München, Germany., Mostert D; Chair of Organic Chemistry II, Technische Universität München, Garching bei München, Germany., Bender J; National Reference Centre for Staphylococci and Enterococci, Robert Koch Institute, Wernigerode, Germany., Layer F; National Reference Centre for Staphylococci and Enterococci, Robert Koch Institute, Wernigerode, Germany., Sieber SA; Chair of Organic Chemistry II, Technische Universität München, Garching bei München, Germany stephan.sieber@tum.de.; Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Centre for Infection Research, Saarbrücken, Germany. |
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Jazyk: | angličtina |
Zdroj: | Applied and environmental microbiology [Appl Environ Microbiol] 2020 Aug 03; Vol. 86 (16). Date of Electronic Publication: 2020 Aug 03 (Print Publication: 2020). |
DOI: | 10.1128/AEM.00933-20 |
Abstrakt: | Triclocarban (TCC), a formerly used disinfectant, kills bacteria via an unknown mechanism of action. A structural hallmark is its N , N' -diaryl urea motif, which is also present in other antibiotics, including the recently reported small molecule PK150. We show here that, like PK150, TCC exhibits an inhibitory effect on Staphylococcus aureus menaquinone metabolism via inhibition of the biosynthesis protein demethylmenaquinone methyltransferase (MenG). However, the activity spectrum (MIC (Copyright © 2020 American Society for Microbiology.) |
Databáze: | MEDLINE |
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