Two new triterpenoid-chromone hybrids from the rhizomes of Actaea cimicifuga L. (syn. Cimicifuga foetida L.) and their cytotoxic activities.

Autor:	Shi QQ; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan, China.; University of the Chinese Academy of Sciences, Beijing, China.; Yunnan Key Laboratory of Natural Medicinal Chemistry Chinese Academy of Sciences, Yunnan, China., Gao Y; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan, China.; University of the Chinese Academy of Sciences, Beijing, China.; Yunnan Key Laboratory of Natural Medicinal Chemistry Chinese Academy of Sciences, Yunnan, China., Lu J; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan, China.; University of the Chinese Academy of Sciences, Beijing, China.; Yunnan Key Laboratory of Natural Medicinal Chemistry Chinese Academy of Sciences, Yunnan, China., Zhou L; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan, China.; University of the Chinese Academy of Sciences, Beijing, China., Qiu MH; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan, China.; University of the Chinese Academy of Sciences, Beijing, China.; Yunnan Key Laboratory of Natural Medicinal Chemistry Chinese Academy of Sciences, Yunnan, China.
Jazyk:	angličtina
Zdroj:	Natural product research [Nat Prod Res] 2022 Jan; Vol. 36 (1), pp. 193-199. Date of Electronic Publication: 2020 Jun 05.
DOI:	10.1080/14786419.2020.1775228
Abstrakt:	Two new triterpenoid-chromone hybrids, cimitriteromones H ( 1 ) and I ( 2 ), along with two known analogues ( 3 , 4 ) were isolated from the phytochemical research on the n- butyl alcohol extracts of Actaea cimicifuga rhizomes. The new compounds were elucidated by spectroscopic experiments and chemical method. The cytotoxic activities of the isolated compounds were tested on A-549/Taxol cell line. Cimitriteromone I ( 2 ) showed cytotoxicity with IC 50 value of 27.14 ± 1.38  μ M comparable to positive control group cisplatin (IC 50 value of 25.80 ± 1.15  μ M).
Databáze:	MEDLINE
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