Optical Coherence Tomography Angiography in Neurodegenerative Disorders.

Autor: Pellegrini M; Ophthalmology Unit, S. Orsola-Malpighi University Hospital, University of Bologna, 40138 Bologna, Italy., Vagge A; University Eye Clinic, DINOGMI, Polyclinic Hospital San Martino IRCCS, 16132 Genoa, Italy., Ferro Desideri LF; University Eye Clinic, DINOGMI, Polyclinic Hospital San Martino IRCCS, 16132 Genoa, Italy., Bernabei F; Ophthalmology Unit, S. Orsola-Malpighi University Hospital, University of Bologna, 40138 Bologna, Italy., Triolo G; Ophthalmology Department, Fatebenefratelli and Ophthalmic Hospital, ASST-Fatebenefratelli-Sacco, 63631 Milan, Italy., Mastropasqua R; Institute of Ophthalmology, University of Modena and Reggio Emilia, 41121 Modena, Italy., Del Noce CD; University Eye Clinic, DINOGMI, Polyclinic Hospital San Martino IRCCS, 16132 Genoa, Italy., Borrelli E; Department of Ophthalmology, Hospital San Raffaele, University Vita Salute San Raffaele, 20132 Milan, Italy., Sacconi R; Department of Ophthalmology, Hospital San Raffaele, University Vita Salute San Raffaele, 20132 Milan, Italy., Iovino C; Department of Surgical Sciences, Eye Clinic, University of Cagliari, 09124 Cagliari, Italy., Di Zazzo AD; Department of Ophthalmology, University Campus Bio-Medico of Rome, 00128 Rome, Italy., Forlini M; Domus Nova Hospital, 48121 Ravenna, Department of Ophthalmology, Ospedale dello Stato della Repubblica di San Marino, 47893 Città di San Marino, San Marino., Giannaccare G; Department of Ophthalmology, University 'Magna Graecia', 88100 Catanzaro, Italy.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2020 Jun 02; Vol. 9 (6). Date of Electronic Publication: 2020 Jun 02.
DOI: 10.3390/jcm9061706
Abstrakt: Retinal microcirculation shares similar features with cerebral small blood vessels. Thus, the retina may be considered an accessible 'window' to detect the microvascular damage occurring in the setting of neurodegenerative disorders. Optical coherence tomography angiography (OCT-A) is a non-invasive imaging modality providing depth resolved images of blood flow in the retina, choroid, and optic nerve. In this review, we summarize the current literature on the application of OCT-A in glaucoma and central nervous system conditions such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Future directions aiming at evaluating whether OCT-A can be an additional biomarker for the early diagnosis and monitoring of neurodegenerative disorders are also discussed.
Databáze: MEDLINE
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