Prognostic value of thiol/disulfide homeostasis in symptomatic patients with heart failure.

Autor: Caliskan HM; Department of Emergency Medicine, Ahi Evran University Training and Research Hospital, Kirsehir, Turkey., Sivri S; Department of Cardiology, Ahi Evran University Training and Research Hospital, Kirsehir, Turkey., Sokmen E; Department of Cardiology, Ahi Evran University Training and Research Hospital, Kirsehir, Turkey., Celik M; Department of Cardiology, Ahi Evran University Training and Research Hospital, Kirsehir, Turkey., Ilanbey B; Department of Biochemistry, Ahi Evran University Training and Research Hospital, Kirsehir, Turkey., Ozbek SC; Department of Cardiology, Ahi Evran University Training and Research Hospital, Kirsehir, Turkey., Celik B; Department of Emergency Medicine, Ahi Evran University Training and Research Hospital, Kirsehir, Turkey.
Jazyk: angličtina
Zdroj: Archives of physiology and biochemistry [Arch Physiol Biochem] 2021 Oct; Vol. 127 (5), pp. 462-467. Date of Electronic Publication: 2020 Jun 04.
DOI: 10.1080/13813455.2020.1773505
Abstrakt: We aimed to examine the role of thiol/disulphide homeostasis (TDH) in heart failure and its stages and the prognosis of heart failure. A total of 140 subjects were included in the study. Total and native thiol levels were higher in the control group compared to the patient groups ( p  < .001). While the average disulphide/total thiol ratio was similar in groups 1 and 2, it was found to be significantly lower in the control group compared to other groups and significantly higher in group 3 compared to other groups ( p  < .05). Mean native thiol and total thiol levels were found lower in patients with mortality compared to surviving patients ( p  < .001). In ROC curve analysis, it was determined that the total thiol level had 81.8% sensitivity and 83.1% specificity, and native thiol level had 81.8% sensitivity and 84.3% specificity. We found that TDH was impaired in favour of disulphide in cases of heart failure.
Databáze: MEDLINE
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