Contemporary human papillomavirus genotyping and correlations to peniscopy, cytology, and histopatology on over 1000 males.

Autor: Truzzi JC; Division of Urology-Fleury Group, Universidade Federal de Sao Paulo, Sao Paulo, Brazil., da Silva ID; Division of Molecular Biology, Department of Gynecology-Fleury Group, Universidade Federal de Sao Paulo, Sao Paulo, Brazil., Freire MP; Division of Urology, Universidade Anhembi Morumbi, Sao Paulo, Brazil., Neto MJ; Division of Urology-Fleury Group, Universidade Federal de Sao Paulo, Sao Paulo, Brazil., Rodrigues FF; Division of Urology-Fleury Group, Universidade Federal de Sao Paulo, Sao Paulo, Brazil., Maciel GA; Division of Molecular Biology-Fleury Group, Universidade de Sao Paulo, Sao Paulo, Brazil., Girardi R; Division of Urology, Universidade Anhembi Morumbi, Sao Paulo, Brazil., Bertolini S; Division of Urology, Universidade Anhembi Morumbi, Sao Paulo, Brazil., Reis LO; Division of UroScience, University of Campinas and Pontifical Catholic University of Campinas, Sao Paulo, Brazil.
Jazyk: angličtina
Zdroj: Diagnostic cytopathology [Diagn Cytopathol] 2020 Nov; Vol. 48 (11), pp. 1021-1026. Date of Electronic Publication: 2020 Jun 04.
DOI: 10.1002/dc.24518
Abstrakt: Objectives: To explore male human papillomavirus (HPV) contemporary genotyping epidemiology and correlations to peniscopy, cytology, and histopatology.
Methods: Medical records of patients who had been submitted to HPV infection screening with genotyping, peniscopy, cytology, and histopathology in a period of 2 years were reviewed. Frequency analysis and correlations between the diagnostic tools were established.
Results: Genotype of 1132 men resulted in 69.2% (784) positivity for HPV DNA, 78% classified as high risk of oncogenesis. Co-infections occurred in 429 (54.7%) and the most frequently identified types were HPV-6, HPV-42, and HPV-16, in 133 (17%), 94 (12%), and 86 (11%) patients, respectively. Positive/negative predictive values of peniscopy, cytology, and histopathology were 83/31%, 92/32%, and 87/33%, respectively. As a result, though significant, the correlations between genotype and non-molecular tests were poor.
Conclusions: In the current contemporary representative male cohort, over two thirds are positive for human HPV DNA, 78% of high risk and with over half co-infections. Though significant, its correlation with non-molecular tests is poor and while the positive predictive values of peniscopy, cytology, and histopatology are between 83% and 92%, their negative predictive values are as low as 31% to 33%.
(© 2020 Wiley Periodicals LLC.)
Databáze: MEDLINE
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