A Novel Aortic Regurgitation Model from Cusp Prolapse with Hemodynamic Validation Using an Ex Vivo Left Heart Simulator.

Autor: Zhu Y; Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.; Department of Bioengineering, Stanford University, Stanford, CA, USA., Imbrie-Moore AM; Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.; Department of Mechanical Engineering, Stanford University, Stanford, CA, USA., Paulsen MJ; Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA., Priromprintr B; Department of Pediatrics, Division of Pediatric Cardiology, Lucile Packard Children's Hospital, Stanford University, Stanford, CA, USA., Park MH; Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.; Department of Mechanical Engineering, Stanford University, Stanford, CA, USA., Wang H; Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA., Lucian HJ; Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA., Farry JM; Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA., Woo YJ; Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA. joswoo@stanford.edu.; Department of Bioengineering, Stanford University, Stanford, CA, USA. joswoo@stanford.edu.; Department of Cardiothoracic Surgery, Falk Cardiovascular Research Center, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA, 94305, USA. joswoo@stanford.edu.
Jazyk: angličtina
Zdroj: Journal of cardiovascular translational research [J Cardiovasc Transl Res] 2021 Apr; Vol. 14 (2), pp. 283-289. Date of Electronic Publication: 2020 Jun 03.
DOI: 10.1007/s12265-020-10038-z
Abstrakt: Although ex vivo simulation is a valuable tool for surgical optimization, a disease model that mimics human aortic regurgitation (AR) from cusp prolapse is needed to accurately examine valve biomechanics. To simulate AR, four porcine aortic valves were explanted, and the commissure between the two largest leaflets was detached and re-implanted 5 mm lower to induce cusp prolapse. Four additional valves were tested in their native state as controls. All valves were tested in a heart simulator while hemodynamics, high-speed videography, and echocardiography data were collected. Our AR model successfully reproduced cusp prolapse with significant increase in regurgitant volume compared with that of the controls (23.2 ± 8.9 versus 2.8 ± 1.6 ml, p = 0.017). Hemodynamics data confirmed the simulation of physiologic disease conditions. Echocardiography and color flow mapping demonstrated the presence of mild to moderate eccentric regurgitation in our AR model. This novel AR model has enormous potential in the evaluation of valve biomechanics and surgical repair techniques. Graphical Abstract.
Databáze: MEDLINE
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