Prevention and treatment of autoimmune diseases with plant virus nanoparticles.

Autor:	Zampieri R; Department of Biotechnology, University of Verona, Verona, Italy.; Diamante srl, Strada Le Grazie, 15, 37134 Verona, Italy., Brozzetti A; Department of Medicine, University of Perugia, Perugia, Italy., Pericolini E; Department of Surgical, Medical, Dental and Morphological Sciences with interest in Transplant, Oncological and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy., Bartoloni E; Department of Medicine, University of Perugia, Perugia, Italy., Gabrielli E; Department of Medicine, University of Perugia, Perugia, Italy., Roselletti E; Department of Medicine, University of Perugia, Perugia, Italy., Lomonosoff G; Department of Biological Chemistry, John Innes Centre, Norwich, UK., Meshcheriakova Y; Department of Biological Chemistry, John Innes Centre, Norwich, UK., Santi L; Department of Agriculture and Forest Sciences, University of La Tuscia, Viterbo, Italy., Imperatori F; Department of Agriculture and Forest Sciences, University of La Tuscia, Viterbo, Italy., Merlin M; Department of Biotechnology, University of Verona, Verona, Italy., Tinazzi E; Department of Medicine, University of Verona, Verona, Italy., Dotta F; Diabetes Unit, Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy., Nigi L; Diabetes Unit, Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.; Umberto Di Mario Foundation ONLUS, Toscana Life Sciences, Siena, Italy., Sebastiani G; Diabetes Unit, Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.; Umberto Di Mario Foundation ONLUS, Toscana Life Sciences, Siena, Italy., Pezzotti M; Department of Biotechnology, University of Verona, Verona, Italy., Falorni A; Department of Medicine, University of Perugia, Perugia, Italy., Avesani L; Department of Biotechnology, University of Verona, Verona, Italy.
Jazyk:	angličtina
Zdroj:	Science advances [Sci Adv] 2020 May 06; Vol. 6 (19), pp. eaaz0295. Date of Electronic Publication: 2020 May 06 (Print Publication: 2020).
DOI:	10.1126/sciadv.aaz0295
Abstrakt:	Plant viruses are natural, self-assembling nanostructures with versatile and genetically programmable shells, making them useful in diverse applications ranging from the development of new materials to diagnostics and therapeutics. Here, we describe the design and synthesis of plant virus nanoparticles displaying peptides associated with two different autoimmune diseases. Using animal models, we show that the recombinant nanoparticles can prevent autoimmune diabetes and ameliorate rheumatoid arthritis. In both cases, this effect is based on a strictly peptide-related mechanism in which the virus nanoparticle acts both as a peptide scaffold and as an adjuvant, showing an overlapping mechanism of action. This successful preclinical testing could pave the way for the development of plant viruses for the clinical treatment of human autoimmune diseases. (Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).)
Databáze:	MEDLINE
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