Cellular contractile forces are nonmechanosensitive.
| Autor: | Feld L; Department of Genetics and Developmental Biology, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel., Kellerman L; Department of Genetics and Developmental Biology, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel., Mukherjee A; Department of Genetics and Developmental Biology, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel., Livne A; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel., Bouchbinder E; Department of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot 7610001, Israel., Wolfenson H; Department of Genetics and Developmental Biology, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel. |
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| Jazyk: | angličtina |
| Zdroj: | Science advances [Sci Adv] 2020 Apr 22; Vol. 6 (17), pp. eaaz6997. Date of Electronic Publication: 2020 Apr 22 (Print Publication: 2020). |
| DOI: | 10.1126/sciadv.aaz6997 |
| Abstrakt: | Cells' ability to apply contractile forces to their environment and to sense its mechanical properties (e.g., rigidity) are among their most fundamental features. Yet, the interrelations between contractility and mechanosensing, in particular, whether contractile force generation depends on mechanosensing, are not understood. We use theory and extensive experiments to study the time evolution of cellular contractile forces and show that they are generated by time-dependent actomyosin contractile displacements that are independent of the environment's rigidity. Consequently, contractile forces are nonmechanosensitive. We further show that the force-generating displacements are directly related to the evolution of the actomyosin network, most notably to the time-dependent concentration of F-actin. The emerging picture of force generation and mechanosensitivity offers a unified framework for understanding contractility. (Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).) |
| Databáze: | MEDLINE |
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