Pre-mRNA Splicing in the Nuclear Landscape.
| Autor: | Carrocci TJ; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA., Neugebauer KM; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Cold Spring Harbor symposia on quantitative biology [Cold Spring Harb Symp Quant Biol] 2019; Vol. 84, pp. 11-20. Date of Electronic Publication: 2020 Jun 03. |
| DOI: | 10.1101/sqb.2019.84.040402 |
| Abstrakt: | Eukaryotic gene expression requires the cumulative activity of multiple molecular machines to synthesize and process newly transcribed pre-messenger RNA. Introns, the noncoding regions in pre-mRNA, must be removed by the spliceosome, which assembles on the pre-mRNA as it is transcribed by RNA polymerase II (Pol II). The assembly and activity of the spliceosome can be modulated by features including the speed of transcription elongation, chromatin, post-translational modifications of Pol II and histone tails, and other RNA processing events like 5'-end capping. Here, we review recent work that has revealed cooperation and coordination among co-transcriptional processing events and speculate on new avenues of research. We anticipate new mechanistic insights capable of unraveling the relative contribution of coupled processing to gene expression. (© 2019 Carrocci and Neugebauer; Published by Cold Spring Harbor Laboratory Press.) |
| Databáze: | MEDLINE |
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