Nutritional status and appetite-regulating hormones in early treatment of acute lymphoblastic leukemia among children and adolescents: a cohort study.

Autor:	Gomes CC; Department of Nutrition, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil., Silva CCGD; Department of Nutrition, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil., Nascimento PRPD; Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil., Lemos TMAM; Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil., Marcadenti A; Postgraduate Program on Health Sciences, Instituto de Cardiologia, Fundação Universitária de Cardiologia, Porto Alegre, RS, Brazil., Markoski MM; Postgraduate Program on Biosciences, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil., Fayh APT; Undergraduate Nutrition Program and Stricto Sensu Postgraduate Programs on Physical Education, Nutrition and Health Sciences, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.
Jazyk:	angličtina
Zdroj:	Sao Paulo medical journal = Revista paulista de medicina [Sao Paulo Med J] 2020 Mar; Vol. 138 (2), pp. 118-125. Date of Electronic Publication: 2020 Jun 01.
DOI:	10.1590/1516-3180.2019.0307.r1.19112019
Abstrakt:	Background: Children with acute lymphoblastic leukemia are at risk of malnutrition, but few studies have described the changes in nutritional status during the different phases of chemotherapy. Objective: To evaluate changes in nutritional status, food intake and appetite-regulating hormones among children and adolescents with acute lymphoblastic leukemia in the first phase of chemotherapy. Design and Setting: Cohort study developed in the pediatric oncology departments of two hospitals in the city of Natal, Rio Grande do Norte, Brazil. Methods: Fourteen children/adolescents (mean age of 7 years; 50% female) with acute lymphoblastic leukemia were monitored over the 28 days of an induction chemotherapy cycle. Anthropometric measurements, 24-hours food weight records and appetite-regulating hormone levels (ghrelin, leptin, insulin and cortisol) were obtained at three different times (before, in the middle and at the end of the induction phase). Results: Most of the patients (85.7%) had normal weight at the beginning of the treatment, and this did not change significantly during the 28 days. Energy and nutrient intakes improved from the start of the treatment to the midpoint, according to the ghrelin levels (from 511.1 ± 8.3 to 519.3 ± 6.6 pg/ml; P = 0.027). Other appetite-regulating hormones did not present changes. Conclusion: Food consumption improves during the first phase of treatment, without alterations in anthropometric nutritional status.
Databáze:	MEDLINE
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