Colorectal cancer in patients under age 50: a five-year experience.

Autor: Silva FMMD; State Department of Health of the Federal District, Brasília, FD, Brazil., Duarte RP; State Department of Health of the Federal District, Brasília, FD, Brazil., Leão CCA; State Department of Health of the Federal District, Brasília, FD, Brazil., Vissoci CM; State Department of Health of the Federal District, Brasília, FD, Brazil., Alvarenga ALAT; Faculty of Health Sciences, Brasília University Centre, Brasília, FD, Brazil., Ramos ABS; Faculty of Health Sciences, Brasília University Centre, Brasília, FD, Brazil., Goulart AEC; State Department of Health of the Federal District, Brasília, FD, Brazil.
Jazyk: English; Portuguese
Zdroj: Revista do Colegio Brasileiro de Cirurgioes [Rev Col Bras Cir] 2020; Vol. 47, pp. e20202406. Date of Electronic Publication: 2020 May 29.
DOI: 10.1590/0100-6991e-20202406
Abstrakt: Objective: to evaluate the clinical characteristics of patients with colorectal cancer under the age of 50 treated at a public hospital in Brasilia over 5 years.
Methods: we conducted a longitudinal, retrospective study, with 184 patients undergoing surgical procedures at the Asa Norte Regional Hospital (HRAN), including those who underwent only biopsy, between January 2013 and January 2018. We divided the patients into two groups: under the age of 50 (n=39) and age equal to or greater than 50 years (n=145). We compared the groups as to age, sex, symptoms, time between symptom onset and diagnosis, family and personal history, tumor location, histopathological characteristics, applied surgical management, staging and mortality.
Results: the group of patients under the age of 50 had more individuals with stage III and IV (p=0.041), more frequent poorly differentiated tumors (10.25% versus 3.52%; p=0.153), and higher incidences of compromised surgical margins (p=0.368), angiolymphatic (p=0.07) and perineural (p=0.007) invasion, which denotes more advanced disease in this group of patients.
Conclusions: the study showed the low effectiveness of population screening methods for colorectal cancer currently used in this population, given the high incidence of the disease and late diagnosis in both groups.
Databáze: MEDLINE