Implications of Long Non-Coding RNAs in Age-Altered Proteostasis.
| Autor: | Catana CS; 1Department of Medical Biochemistry, 'Iuliu Haţieganu' University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca, Romania., Crișan CA; 2Department of Neurosciences, 'Iuliu Haţieganu' University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca, Romania., Opre D; 3Department of Psychology, Babeș-Bolyai University, Cluj-Napoca, Romania., Berindan-Neagoe I; 4MEDFUTURE - Research Center for Advanced Medicine, Cluj-Napoca, Romania.; 5Research Center for Functional Genomics, Biomedicine and Translational Medicine, Institute of Doctoral Studies, 'Iuliu Hatieganu' University of Medicine and Pharmacy, Cluj-Napoca, Romania.; 6Department of Experimental Pathology, 'Prof. Dr. Ion Chiricuta' Oncology Institute, Cluj-Napoca, Romania. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Aging and disease [Aging Dis] 2020 May 09; Vol. 11 (3), pp. 692-704. Date of Electronic Publication: 2020 May 09 (Print Publication: 2020). |
| DOI: | 10.14336/AD.2019.0814 |
| Abstrakt: | This review aims to summarize the current knowledge on how lncRNAs are influencing aging and cancer metabolism. Recent research has shown that senescent cells re-enter cell-cycle depending on intrinsic or extrinsic factors, thus restoring tissue homeostasis in response to age-related diseases (ARDs). Furthermore, maintaining proteostasis or cellular protein homeostasis requires a correct quality control (QC) of protein synthesis, folding, conformational stability, and degradation. Long non-coding RNAs (lncRNAs), transcripts longer than 200 nucleotides, regulate gene expression through RNA-binding protein (RBP) interaction. Their association is linked to aging, an event of proteostasis collapse. The current review examines approaches that lead to recognition of senescence-associated lncRNAs, current methodologies, potential challenges that arise from studying these molecules, and their crucial implications in clinical practice. Competing Interests: Conflict of Interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright: © 2020 Catana et al.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|