The correlation between oxygen saturation indices and the standard obstructive sleep apnea severity.

Autor: Wali SO; Sleep Medicine Research Group, Sleep Medicine and Research Center, King Abdulaziz University Hospital, Jeddah, Saudi Arabia., Abaalkhail B; Department of Family and Community Medicine, King Abdulaziz University, Jeddah, Saudi Arabia., AlQassas I; International Medical Center, Jeddah, Saudi Arabia., Alhejaili F; Sleep Medicine Research Group, Sleep Medicine and Research Center, King Abdulaziz University Hospital, Jeddah, Saudi Arabia., Spence DW; Independent Researcher, Toronto, ON, Canada., Pandi-Perumal SR; Somnogen Canada Inc., Toronto, ON, Canada.
Jazyk: angličtina
Zdroj: Annals of thoracic medicine [Ann Thorac Med] 2020 Apr-Jun; Vol. 15 (2), pp. 70-75. Date of Electronic Publication: 2020 Apr 03.
DOI: 10.4103/atm.ATM_215_19
Abstrakt: Objective: Currently accepted guidelines categorize obstructive sleep apnea (OSA) severity according to the Apnea-Hypopnea Index (AHI). However, it is unclear how to best define OSA severity. The present study sought to evaluate the concurrent validity of the widely accepted AHI by correlating it with various oxygen saturation (SpO 2 ) and polysomnographic parameters.
Methods: The study utilized the data of a previous survey concerning the prevalence of OSA among a middle-aged Saudi population ( n = 2682). Among the 346 individuals who underwent polysomnography, 178 had total sleep times of at least 240 min with rapid eye movement (REM) sleep and were included in the study. The standard classification of OSA severity was compared with different SpO 2 and polysomnographic parameters.
Results: The study found that there were correlations between the standard OSA severity based on AHI severity classification and different SpO 2 and polysomnographic parameters, including the desaturation index (DI), the sum of all desaturations, desaturation below 90%, the average duration of respiratory events, and indices of total arousals and respiratory arousals. All of these parameters correlated directly with OSA severity classification ( P < 0.001 for each). However, REM sleep duration and SpO 2 nadir were inversely correlated with OSA severity ( P < 0.003 and < 0.001, respectively). In addition, only the DI, SpO 2 nadir, and respiratory arousal index were predictors of OSA severity, as determined through a multiple logistic regression analysis.
Conclusion: Our findings support the clinical reliability of the currently used standard classification of OSA severity based on the AHI.
Competing Interests: The authors have read the journal's policy and have the following potential conflicts. This study was not an industry-supported study. S.R. Pandi-Perumal is a stockholder and the President and Chief Executive Officer of Somnogen Canada Inc., a Canadian Corporation. This does not alter his adherence to all journal policies. He declares that he has no competing interests that might be perceived to influence the content of this article. Other remaining authors declare that they have no proprietary, financial, professional, or any other personal interest of any nature or kind in any product of services and/or company that could be construed or considered as a potential conflict of interest that might have influenced the views expressed in this manuscript.
(Copyright: © 2020 Annals of Thoracic Medicine.)
Databáze: MEDLINE
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