| Autor: |
Sukhacheva TV; A. N. Bakulev National Medical Research Center of Cardiovascular Surgery, Ministry of Health of Russian Federation, Moscow, Russia. tatiana@box.ru., Nizyaeva NV; V. I. Kulakov National Research Medical Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russian Federation, Moscow, Russia., Samsonova MV; Research Institute of Pulmonology, Federal Medical-Biological Agency of Russian Federation, Moscow, Russia., Chernyaev AL; Research Institute of Pulmonology, Federal Medical-Biological Agency of Russian Federation, Moscow, Russia., Shchegolev AI; V. I. Kulakov National Research Medical Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russian Federation, Moscow, Russia., Serov RA; A. N. Bakulev National Medical Research Center of Cardiovascular Surgery, Ministry of Health of Russian Federation, Moscow, Russia. |
| Abstrakt: |
Telocytes, a new type of interstitial stem cells with long thin processes that form a three-dimensional network around cardiomyocytes, vessels, and nerve fibers were described in the myocardium of children with tetralogy of Fallot. Two types of morphologically different telocytes, spindle-shaped and rounded, were identified. Contacts of telocytes with stem cells and interstitial macrophages were found. Telocytes were more common in the immature myocardium, where the assembly of myofibrils in cardiomyocytes was not completed and small Ki-67 + cardiomyocyte progenitor cells were present. Telocytes expressed immunohistochemical markers CD117, vimentin, CD34, and CD44. Localization and ultrastructural characteristics of telocytes suggested their participation in stem cell differentiation, coordination of neoangiogenesis, and paracrine regulation of all components of the interstitium. |
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