Estrogen-related mechanisms in sex differences of hypertension and target organ damage.

Autor: Sabbatini AR; Cell Signalling Research Group, School of Life Sciences, University of Nottingham, Nottingham, UK., Kararigas G; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. georgekararigas@gmail.com.; DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany. georgekararigas@gmail.com.
Jazyk: angličtina
Zdroj: Biology of sex differences [Biol Sex Differ] 2020 Jun 01; Vol. 11 (1), pp. 31. Date of Electronic Publication: 2020 Jun 01.
DOI: 10.1186/s13293-020-00306-7
Abstrakt: Hypertension (HTN) is a primary risk factor for cardiovascular (CV) events, target organ damage (TOD), premature death and disability worldwide. The pathophysiology of HTN is complex and influenced by many factors including biological sex. Studies show that the prevalence of HTN is higher among adults aged 60 and over, highlighting the increase of HTN after menopause in women. Estrogen (E2) plays an important role in the development of systemic HTN and TOD, exerting several modulatory effects. The influence of E2 leads to alterations in mechanisms regulating the sympathetic nervous system, renin-angiotensin-aldosterone system, body mass, oxidative stress, endothelial function and salt sensitivity; all associated with a crucial inflammatory state and influenced by genetic factors, ultimately resulting in cardiac, vascular and renal damage in HTN. In the present article, we discuss the role of E2 in mechanisms accounting for the development of HTN and TOD in a sex-specific manner. The identification of targets with therapeutic potential would contribute to the development of more efficient treatments according to individual needs.
Databáze: MEDLINE
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