Docosahexaenoic Acid-Rich Fish Oil Supplementation Reduces Kinase Associated with Insulin Resistance in Overweight and Obese Midlife Adults.

Autor:	Thota RN; Nutraceuticals Research Program, School of Biomedical Sciences & Pharmacy, University of Newcastle, Callaghan NSW 2308, Australia.; Riddet Institute, Massey University, Palmerston North 4474, New Zealand., Rosato JI; Nutraceuticals Research Program, School of Biomedical Sciences & Pharmacy, University of Newcastle, Callaghan NSW 2308, Australia.; School of Health Sciences, University of Newcastle, Callaghan NSW 2308, Australia., Burrows TL; School of Health Sciences, University of Newcastle, Callaghan NSW 2308, Australia., Dias CB; Nutraceuticals Research Program, School of Biomedical Sciences & Pharmacy, University of Newcastle, Callaghan NSW 2308, Australia.; Department of Biomedical Sciences, Macquarie University, North Ryde NSW 2109, Australia., Abbott KA; Nutraceuticals Research Program, School of Biomedical Sciences & Pharmacy, University of Newcastle, Callaghan NSW 2308, Australia., Martins RN; Department of Biomedical Sciences, Macquarie University, North Ryde NSW 2109, Australia.; School of Medical Sciences, Edith Cowan University, Joondalup WA 6027, Australia., Garg ML; Nutraceuticals Research Program, School of Biomedical Sciences & Pharmacy, University of Newcastle, Callaghan NSW 2308, Australia.; Riddet Institute, Massey University, Palmerston North 4474, New Zealand.
Jazyk:	angličtina
Zdroj:	Nutrients [Nutrients] 2020 May 30; Vol. 12 (6). Date of Electronic Publication: 2020 May 30.
DOI:	10.3390/nu12061612
Abstrakt:	Targeting kinases linked to insulin resistance (IR) and inflammation may help in reducing the risk of type 2 diabetes (T2D) and Alzheimer's disease (AD) in its early stages. This study aimed to determine whether DHA-rich fish oil supplementation reduces glycogen synthase kinase (GSK-3), which is linked to both IR and AD. Baseline and post-intervention plasma samples from 58 adults with abdominal obesity (Age: 51.7 ± 1.7 years, BMI: 31.9 ± 0.8 kg/m 2 ) were analysed for outcome measures. Participants were allocated to 2 g DHA-rich fish oil capsules (860 mg DHA + 120 mg EPA) (n = 31) or placebo capsules (n = 27) per day for 12 weeks. Compared to placebo, DHA-rich fish oil significantly reduced GSK-3β by -2.3 ± 0.3 ng/mL. An inverse correlation ( p < 0.05) was found between baseline insulin and IR and their changes following intervention only in participants with C-reactive protein levels higher than 2.4 mg/L. DHA-rich fish oil reduces GSK-3 and IR, suggesting a potential role of long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) in ameliorating AD risk.
Databáze:	MEDLINE
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