A Systematic Review of the Anti-inflammatory Effects of Gallium Compounds.

Autor:	de Albuquerque Wanderley Sales V; Laboratorio de Tecnologia dos Medicamentos, Federal University of Pernambuco (UFPE), Recife-PE, Brazil., Timóteo TRR; Laboratorio de Tecnologia dos Medicamentos, Federal University of Pernambuco (UFPE), Recife-PE, Brazil., da Silva NM; Laboratorio de Tecnologia dos Medicamentos, Federal University of Pernambuco (UFPE), Recife-PE, Brazil., de Melo CG; Laboratorio de Tecnologia dos Medicamentos, Federal University of Pernambuco (UFPE), Recife-PE, Brazil., Ferreira AS; Laboratorio de Tecnologia dos Medicamentos, Federal University of Pernambuco (UFPE), Recife-PE, Brazil., de Oliveira MVG; Laboratorio de Tecnologia dos Medicamentos, Federal University of Pernambuco (UFPE), Recife-PE, Brazil., de Oliveira Silva E; Laboratorio de Tecnologia dos Medicamentos, Federal University of Pernambuco (UFPE), Recife-PE, Brazil., Dos Santos Mendes LM; Laboratorio de Tecnologia dos Medicamentos, Federal University of Pernambuco (UFPE), Recife-PE, Brazil., Rolim LA; Central de Analise de Farmacos, Medicamentos e Alimentos, Federal University of Vale do Sao Francisco (UNIVASF), Petrolina-PE, Brazil., Neto PJR; Laboratorio de Tecnologia dos Medicamentos, Federal University of Pernambuco (UFPE), Recife-PE, Brazil.
Jazyk:	angličtina
Zdroj:	Current medicinal chemistry [Curr Med Chem] 2021; Vol. 28 (10), pp. 2062-2076.
DOI:	10.2174/0929867327666200525160556
Abstrakt:	Background: Inflammation is an essential response provided by the immune system, ensuring the survival during microbial infection, tissue injury and other noxious conditions. However, prolonged inflammatory processes are often associated with severe side effects on health. Objective: This systematic review aimed to provide the evidence in the literature of the preclinical and human anti-inflammatory activity of gallium compounds from 2000 to 2019 focused on elucidating the mechanisms involved in the inflammatory process. Methods: Seven bibliographical databases were consulted (PubMed, Medline, ScienceDirect, Scopus, Springer, Web of Science, and EBSCOhost). The selection of appropriate publications and writing of this systematic review were based on the guidelines mentioned in the PRISMA statement. Moreover, the assessment of the methodological quality of the selected studies was also performed. Results: From a total of 3018 studies, 16 studies were included in this paper based on our eligibility criteria, which showed promising and consistent results. Conclusion: Further research concerning specific inflammatory conditions is required. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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