Retrospective cohort studies of repeat donors reveal donor-dependent variability in the recovery of transfused platelets.

Autor: Stefely JA; Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Medical Scientist Training Program, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA., Gailey M; Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA., Knudson M; Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA., Dumont LJ; Vitalant Research Institute, Denver, Colorado, USA.; Department of Pathology and Laboratory Medicine, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.; Department of Pathology, University of Colorado School of Medicine, Denver, Colorado, USA., Raife TJ; Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA., Samia NI; Department of Statistics, Northwestern University, Evanston, Illinois, USA.
Jazyk: angličtina
Zdroj: Transfusion [Transfusion] 2020 Aug; Vol. 60 (8), pp. 1837-1845. Date of Electronic Publication: 2020 Jun 01.
DOI: 10.1111/trf.15865
Abstrakt: Background: The in vivo recovery of transfused platelets is variable and often unpredictable. Although many recipient-dependent factors are well described, donor-dependent variables remain poorly understood.
Study Design and Methods: To explore donor-dependent variables we conducted 2 retrospective studies of platelet transfusion outcomes in repeat donors. One study analyzed multiple autologous, radiolabeled platelet transfusions, and a second study analyzed multiple clinical platelet transfusions from a small cohort of repeat donors.
Results: In 36 subjects, multiple within-subject determinations of recovery and survival of radiolabeled autologous platelets revealed a relative consistency in platelet recoveries within donors compared to the range of recoveries among donors. Intraclass correlation coefficients for platelet recovery were 43% to 93%. In 524 ABO-compatible clinical platelet transfusions derived from seven donors, a linear mixed-effects model revealed significant donor-dependent differences in corrected count increments for units stored for 4 or 5 days.
Conclusions: These two studies indicate reproducible donor-dependent differences in transfused platelet recovery, suggesting a possible heritable influence on the quality of transfused platelets.
(© 2020 AABB.)
Databáze: MEDLINE
Externí odkaz: