Hallucinating schizophrenia patients have longer left arcuate fasciculus fiber tracks: a DTI tractography study.

Autor: Falkenberg LE; Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway., Westerhausen R; Department of Psychology, University of Oslo, Norway., Johnsen E; Division of Psychiatry and NORMENT Center of Excellence, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Norway., Kroken R; Division of Psychiatry and NORMENT Center of Excellence, Haukeland University Hospital, Bergen, Norway., Løberg EM; Division of Psychiatry and NORMENT Center of Excellence, Haukeland University Hospital, Bergen, Norway; Department of Addiction Medicine, Haukeland University Hospital, Bergen, Norway; Department of Clinical Psychology, University of Bergen, Norway., Beresniewicz J; Department of Biological and Medical Psychology, University of Bergen, Norway., Kazimierczak K; Department of Biological and Medical Psychology, University of Bergen, Norway., Kompus K; Department of Biological and Medical Psychology, University of Bergen, Norway., Ersland L; Department of Biological and Medical Psychology, University of Bergen, Norway; Department of Clinical Engineering, Haukeland University Hospital, Bergen, Norway., Sandøy LB; Department of Biological and Medical Psychology, University of Bergen, Norway., Hugdahl K; Division of Psychiatry and NORMENT Center of Excellence, Haukeland University Hospital, Bergen, Norway; Department of Biological and Medical Psychology, University of Bergen, Norway; Department of Radiology, Haukeland University Hospital, Bergen, Norway. Electronic address: hugdahl@uib.no.
Jazyk: angličtina
Zdroj: Psychiatry research. Neuroimaging [Psychiatry Res Neuroimaging] 2020 Aug 30; Vol. 302, pp. 111088. Date of Electronic Publication: 2020 May 22.
DOI: 10.1016/j.pscychresns.2020.111088
Abstrakt: The arcuate fasciculus (AF) has been implicated in the pathology behind schizophrenia and auditory verbal hallucinations (AVHs). White matter tracts forming the arcuate fasciculus can be quantified and visualized using diffusion tensor imaging (DTI) tractography. Although there have been a number of studies on this topic, the results have been conflicting. Studying the underlying white matter structure of the AF could shed light on the constrains for interaction between temporal and frontal language areas in AVHs. The participants were 66 patients with a schizophrenia diagnosis, where AVHs were defined from the Positive and Negative Syndrome Scale (PANSS), and compared with a healthy control group. DTI was performed on a 3T MR scanner, and tensor estimation was done using deterministic streamline tractography. Statistical analysis of the data showed significantly longer reconstructed tracks along the AF in patients with severe and frequent AVHs, as well as an overall significant asymmetry with longer tracks in the left compared to the right side. In addition, there were significant positive correlations between PANSS scores and track length, track volume, and number of track streamlines for the posterior AF segment on the left side. It is concluded that the present DTI results may have implications for interpretations of functional imaging results.
Competing Interests: Declaration of Competing Interests Co-authors Kenneth Hugdahl and Lars Ersland owns shares in the company NordicNeurolab Inc. (https://nordicneurolab.com/) that produced add-on equipment for the acquisition of the MR data. Kenneth Hugdahl and Lars Ersland declare no conflict of interest, as do all other co-authors.
(Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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