| Autor: |
Riccardi N; Department of Infectious, Tropical Diseases & Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, Verona, Italy.; StopTB Italia Onlus, Milan, Italy., Giacomelli A; StopTB Italia Onlus, Milan, Italy.; III Infectious Diseases Unit, ASST Fatebenefratelli Sacco, Milano, Italy.; Department of Biomedical & Clinical Sciences 'Luigi Sacco', Università degli Studi di Milano, Italy., Canetti D; StopTB Italia Onlus, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.; Clinic of Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy., Comelli A; Department of Infectious & Tropical Diseases, Spedali Civili, Brescia, Italy., Intini E; StopTB Italia Onlus, Milan, Italy.; Division of Respiratory Medicine, A. Gemelli University Hospital, Catholic University of the Sacred Heart, Rome, Italy., Gaiera G; Clinic of Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy., Diaw MM; StopTB Italia Onlus, Milan, Italy.; Médecin coordonnateur lutte contre la TB, Région médicale de Thiès, Thiès, Sénégal., Udwadia Z; Department of Pulmonary Medicine, PD. Hinduja National Hospital & Medical Research Centre, Mumbai, Maharashtra, India., Besozzi G; StopTB Italia Onlus, Milan, Italy., Codecasa L; StopTB Italia Onlus, Milan, Italy.; Regional TB Reference Centre & Laboratory, Villa Marelli Institute/ASST Niguarda Ca' Granda, Milan, Italy., Biagio AD; StopTB Italia Onlus, Milan, Italy.; Clinic of Infectious Diseases, IRCCS AOU San Martino-IST, Genoa, Italy. |
| Abstrakt: |
Clofazimine (CFZ), an old hydrophobic riminophenazine, has a wide range of antimycobacterial activity ranging from leprosy to nontuberculous mycobacterial diseases. CFZ has several advantages such as a favorable pharmacokinetic profile, dose-dependent side effects as well as low price. In this narrative review, we have assessed the clinical development of CFZ, starting from the potential in vitro mechanism of actions, to the spectrum of side effects and potential drug-drug interactions, highlighting its current place in therapy and future possible use in leprosy, nontuberculous mycobacterial diseases and drug-resistant tuberculosis. |
