Mechanisms and Regulation of RNA Condensation in RNP Granule Formation.

Autor: Tauber D; Department of Biochemistry, University of Colorado Boulder, Boulder, CO 80308, USA., Tauber G; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA., Parker R; Department of Biochemistry, University of Colorado Boulder, Boulder, CO 80308, USA; Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, CO 80308, USA. Electronic address: roy.parker@colorado.edu.
Jazyk: angličtina
Zdroj: Trends in biochemical sciences [Trends Biochem Sci] 2020 Sep; Vol. 45 (9), pp. 764-778. Date of Electronic Publication: 2020 May 11.
DOI: 10.1016/j.tibs.2020.05.002
Abstrakt: Ribonucleoprotein (RNP) granules are RNA-protein assemblies that are involved in multiple aspects of RNA metabolism and are linked to memory, development, and disease. Some RNP granules form, in part, through the formation of intermolecular RNA-RNA interactions. In vitro, such trans RNA condensation occurs readily, suggesting that cells require mechanisms to modulate RNA-based condensation. We assess the mechanisms of RNA condensation and how cells modulate this phenomenon. We propose that cells control RNA condensation through ATP-dependent processes, static RNA buffering, and dynamic post-translational mechanisms. Moreover, perturbations in these mechanisms can be involved in disease. This reveals multiple cellular mechanisms of kinetic and thermodynamic control that maintain the proper distribution of RNA molecules between dispersed and condensed forms.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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