| Autor: |
Barbaz BS; Research Department, CIBA-GEIGY Corporation, Summit, NJ 07901., Hall NR, Liebman JM |
| Jazyk: |
angličtina |
| Zdroj: |
Peptides [Peptides] 1988 Nov-Dec; Vol. 9 (6), pp. 1295-300. |
| DOI: |
10.1016/0196-9781(88)90195-7 |
| Abstrakt: |
The conditions under which CCK-8-S may block opiate-induced analgesia were examined in detail. A U-shaped dose-response relationship was observed for the ability of CCK-8-S to attenuate (by approximately 50%, at most) morphine-induced tail flick analgesia. The analgesic effects of morphine in the hot plate or acetic acid-induced stretching tests were not altered by CCK-8-S at doses that antagonized morphine in the tail flick test. Tail flick latency elevations induced by meptazinol, a putative mu-1 receptor agonist, were also attenuated by CCK-8-S according to a U-shaped dose-response relationship, but those induced by U-50,488, a kappa agonist, were not antagonized by CCK-8-S doses that attenuated morphine analgesia. Thus, the ability of CCK-8-S to antagonize opiate analgesia does not follow a conventional dose-response relationship, does not extend to all tests of analgesia and may not extend to all opioid drugs. Analgesia mediated by the mu-1 opioid receptor subtype may be more amenable to antagonism by CCK-8-S than that mediated by the kappa receptor subtype. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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