Brain Function Differences in Children With Type 1 Diabetes: A Functional MRI Study of Working Memory.

Autor:	Foland-Ross LC; Center for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA lfolandross@stanford.edu., Tong G; Center for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA., Mauras N; Division of Endocrinology, Diabetes and Metabolism, Nemours Children's Health System, Jacksonville, FL., Cato A; Division of Neurology, Nemours Children's Health System, Jacksonville, FL., Aye T; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA., Tansey M; Department of Pediatrics, The University of Iowa, Iowa City, IA., White NH; Department of Pediatrics, Washington University in St. Louis and the St. Louis Children's Hospital, St. Louis, MO., Weinzimer SA; Pediatric Endocrinology, Yale University, New Haven, CT., Englert K; Division of Endocrinology, Diabetes and Metabolism, Nemours Children's Health System, Jacksonville, FL., Shen H; Center for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA., Mazaika PK; Center for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA., Reiss AL
Jazyk:	angličtina
Zdroj:	Diabetes [Diabetes] 2020 Aug; Vol. 69 (8), pp. 1770-1778. Date of Electronic Publication: 2020 May 29.
DOI:	10.2337/db20-0123
Abstrakt:	Glucose is a primary fuel source to the brain, yet the influence of dysglycemia on neurodevelopment in children with type 1 diabetes remains unclear. We examined brain activation using functional MRI in 80 children with type 1 diabetes (mean ± SD age 11.5 ± 1.8 years; 46% female) and 47 children without diabetes (control group) (age 11.8 ± 1.5 years; 51% female) as they performed a visuospatial working memory (N-back) task. Results indicated that in both groups, activation scaled positively with increasing working memory load across many areas, including the frontoparietal cortex, caudate, and cerebellum. Between groups, children with diabetes exhibited reduced performance on the N-back task relative to children in the control group, as well as greater modulation of activation (i.e., showed greater increase in activation with higher working memory load). Post hoc analyses indicated that greater modulation was associated in the diabetes group with better working memory function and with an earlier age of diagnosis. These findings suggest that increased modulation may occur as a compensatory mechanism, helping in part to preserve working memory ability, and further, that children with an earlier onset require additional compensation. Future studies that test whether these patterns change as a function of improved glycemic control are warranted. (© 2020 by the American Diabetes Association.)
Databáze:	MEDLINE
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